A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore

Sulfur-aromatic interactions occur in the majority of protein structures, yet little is known about their functional roles in ion channels. Here, we describe a novel molecular motif, the M101 gate latch, which is essential for gating of human Orai1 channels via its sulfur-aromatic interactions with...

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Detalles Bibliográficos
Autores principales: Yeung, Priscilla S-W, Ing, Christopher E, Yamashita, Megumi, Pomès, Régis, Prakriya, Murali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679135/
https://www.ncbi.nlm.nih.gov/pubmed/33124982
http://dx.doi.org/10.7554/eLife.60751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679135/
https://www.ncbi.nlm.nih.gov/pubmed/33124982
http://dx.doi.org/10.7554/eLife.60751

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