Defective memory engram reactivation underlies impaired fear memory recall in Fragile X syndrome

Fragile X syndrome (FXS) is an X chromosome-linked disease associated with severe intellectual disabilities. Previous studies using the Fmr1 knockout (KO) mouse, an FXS mouse model, have attributed behavioral deficits to synaptic dysfunctions. However, how functional deficits at neural network level...

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Detalles Bibliográficos
Autores principales: Li, Jie, Jiang, Rena Y, Arendt, Kristin L, Hsu, Yu-Tien, Zhai, Sophia R, Chen, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679137/
https://www.ncbi.nlm.nih.gov/pubmed/33215988
http://dx.doi.org/10.7554/eLife.61882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679137/
https://www.ncbi.nlm.nih.gov/pubmed/33215988
http://dx.doi.org/10.7554/eLife.61882

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