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Desipramine, commonly used as a noradrenergic neuroprotectant in 6-OHDA-lesions, leads to local functional changes in the urinary bladder and gastrointestinal tract in healthy rats

The 6-hydroxydopamine (6-OHDA) rat model is one of the most common animal models of Parkinson's disease. When experimentally inducing dopaminergic neurodegeneration in the nigrostriatal pathway using 6-OHDA, the noradrenergic reuptake inhibitor desipramine is often systemically injected in orde...

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Detalles Bibliográficos
Autores principales:	Murillo, Maria del Pilar, Aronsson, Patrik, Winder, Michael, Carlsson, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679251/ https://www.ncbi.nlm.nih.gov/pubmed/33251357 http://dx.doi.org/10.1016/j.heliyon.2020.e05472

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