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Different effects of tryptophan 2,3-dioxygenase inhibition on SK-Mel-28 and HCT-8 cancer cell lines

PURPOSE: Indoleamine 2,3-dioxygenase-1 (IDO1) and more recently, tryptophan 2,3-dioxygenase (TDO), are tryptophan-catabolizing enzymes with immunoregulatory properties in cancer. IDO1 is more expressed than TDO in many tumours including melanomas; however, IDO inhibitors did not give expected result...

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Detalles Bibliográficos
Autores principales:	Paccosi, Sara, Cecchi, Marta, Silvano, Angela, Fabbri, Sergio, Parenti, Astrid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Original Article – Cancer Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679327/ https://www.ncbi.nlm.nih.gov/pubmed/32776284 http://dx.doi.org/10.1007/s00432-020-03351-2

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