Cargando…
CMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects
Parkinson's disease (PD) is a neurodegenerative disorder for which only symptomatic treatments are available. Repurposing drugs that target α-synuclein aggregation, considered one of the main drivers of PD progression, could accelerate the development of disease-modifying therapies. In this wor...
Autores principales: | González-Lizárraga, Florencia, Ploper, Diego, Ávila, César L., Socías, Sergio B., dos-Santos-Pereira, Mauricio, Machín, Belén, Del-Bel, Elaine, Michel, Patrick Pierre, Pietrasanta, Lía I., Raisman-Vozari, Rita, Chehín, Rosana |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679368/ https://www.ncbi.nlm.nih.gov/pubmed/33219264 http://dx.doi.org/10.1038/s41598-020-76927-0 |
Ejemplares similares
-
Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity
por: Medina, Luciana, et al.
Publicado: (2021) -
Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates
por: Acuña, Leonardo, et al.
Publicado: (2019) -
Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species
por: González-Lizárraga, Florencia, et al.
Publicado: (2017) -
Neuroprotective Effects of a Novel Demeclocycline Derivative Lacking Antibiotic Activity: From a Hit to a Promising Lead Compound
por: Tomas-Grau, Rodrigo, et al.
Publicado: (2022) -
The Chemically-Modified Tetracycline COL-3 and Its Parent Compound Doxycycline Prevent Microglial Inflammatory Responses by Reducing Glucose-Mediated Oxidative Stress
por: Ferreira Junior, Nilson Carlos, et al.
Publicado: (2021)