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Chronic exposure to TNF reprograms cell signaling pathways in fibroblast-like synoviocytes by establishing long-term inflammatory memory

Fibroblast-like synoviocytes (FLS) play a critical role in the pathogenesis of rheumatoid arthritis (RA). Chronic inflammation induces transcriptomic and epigenetic modifications that imparts a persistent catabolic phenotype to the FLS, despite their dissociation from the inflammatory environment. W...

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Detalles Bibliográficos
Autores principales:	Gangishetti, Umesh, Ramirez-Perez, Sergio, Jones, Kyle, Arif, Abul, Drissi, Hicham, Bhattaram, Pallavi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679373/ https://www.ncbi.nlm.nih.gov/pubmed/33219307 http://dx.doi.org/10.1038/s41598-020-77380-9

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