Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers

Transcriptional dysregulation, which can be caused by genetic and epigenetic alterations, is a fundamental feature of many cancers. A key cytoprotective transcriptional activator, NRF2, is often aberrantly activated in non-small cell lung cancers (NSCLCs) and supports both aggressive tumorigenesis a...

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Detalles Bibliográficos
Autores principales: Okazaki, Keito, Anzawa, Hayato, Liu, Zun, Ota, Nao, Kitamura, Hiroshi, Onodera, Yoshiaki, Alam, Md. Morshedul, Matsumaru, Daisuke, Suzuki, Takuma, Katsuoka, Fumiki, Tadaka, Shu, Motoike, Ikuko, Watanabe, Mika, Hayasaka, Kazuki, Sakurada, Akira, Okada, Yoshinori, Yamamoto, Masayuki, Suzuki, Takashi, Kinoshita, Kengo, Sekine, Hiroki, Motohashi, Hozumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679411/
https://www.ncbi.nlm.nih.gov/pubmed/33219226
http://dx.doi.org/10.1038/s41467-020-19593-0

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