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Cepharanthine induces ROS stress in glioma and neuronal cells via modulation of VDAC permeability

Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid. Molecular dynamics studies show that CEP interacts with Voltage-dependent anion channel (VDAC), inducing the voltage-independent channel narrowing. In the new conformation, transport between mitochondria and cytoplasm is altered, which leads t...

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Detalles Bibliográficos
Autores principales:	Cierluk, Karolina, Szlasa, Wojciech, Rossowska, Joanna, Tarek, Mounir, Szewczyk, Anna, Saczko, Jolanta, Kulbacka, Julita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679435/ https://www.ncbi.nlm.nih.gov/pubmed/33250643 http://dx.doi.org/10.1016/j.jsps.2020.08.026

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