Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain

ATG16L1, an autophagy mediator that specifies the site of LC3 lipidation, includes a C-terminal domain formed by 7 WD40-type repeats (WD40 domain, WDD), the function of which is unclear. Here we show that the WDD interacts with the intracellular domain of cytokine receptors to regulate their signali...

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Detalles Bibliográficos
Autores principales: Serramito-Gómez, Inmaculada, Boada-Romero, Emilio, Villamuera, Raquel, Fernández-Cabrera, Álvaro, Cedillo, José Luis, Martín-Regalado, Ángela, Carding, Simon, Mayer, Uli, Powell, Penny P., Wileman, Thomas, García-Higuera, Irene, Pimentel-Muiños, Felipe X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679444/
https://www.ncbi.nlm.nih.gov/pubmed/33219218
http://dx.doi.org/10.1038/s41467-020-19670-4

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