Robust alternative to the righting reflex to assess arousal in rodents

The righting reflex (RR) is frequently used to assess level of arousal and applied to animal models of a range of neurological disorders. RR produces a binary result that, when positive, is used to infer restoration of consciousness, often without further behavioral corroboration. We find that RR is...

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Autores principales: Gao, Sijia, Calderon, Diany Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679463/
https://www.ncbi.nlm.nih.gov/pubmed/33219247
http://dx.doi.org/10.1038/s41598-020-77162-3
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author Gao, Sijia
Calderon, Diany Paola
author_facet Gao, Sijia
Calderon, Diany Paola
author_sort Gao, Sijia
collection PubMed
description The righting reflex (RR) is frequently used to assess level of arousal and applied to animal models of a range of neurological disorders. RR produces a binary result that, when positive, is used to infer restoration of consciousness, often without further behavioral corroboration. We find that RR is an unreliable metric for arousal/recovery of consciousness. Instead, cortical activity and motor behavior that accompany RR are a non-binary, superior criterion that accurately calibrates and establishes level of arousal in rodents.
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spelling pubmed-76794632020-11-24 Robust alternative to the righting reflex to assess arousal in rodents Gao, Sijia Calderon, Diany Paola Sci Rep Article The righting reflex (RR) is frequently used to assess level of arousal and applied to animal models of a range of neurological disorders. RR produces a binary result that, when positive, is used to infer restoration of consciousness, often without further behavioral corroboration. We find that RR is an unreliable metric for arousal/recovery of consciousness. Instead, cortical activity and motor behavior that accompany RR are a non-binary, superior criterion that accurately calibrates and establishes level of arousal in rodents. Nature Publishing Group UK 2020-11-20 /pmc/articles/PMC7679463/ /pubmed/33219247 http://dx.doi.org/10.1038/s41598-020-77162-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Gao, Sijia
Calderon, Diany Paola
Robust alternative to the righting reflex to assess arousal in rodents
title Robust alternative to the righting reflex to assess arousal in rodents
title_full Robust alternative to the righting reflex to assess arousal in rodents
title_fullStr Robust alternative to the righting reflex to assess arousal in rodents
title_full_unstemmed Robust alternative to the righting reflex to assess arousal in rodents
title_short Robust alternative to the righting reflex to assess arousal in rodents
title_sort robust alternative to the righting reflex to assess arousal in rodents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679463/
https://www.ncbi.nlm.nih.gov/pubmed/33219247
http://dx.doi.org/10.1038/s41598-020-77162-3
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