In Vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes–Associated Single Nucleotide Polymorphisms

Many single nucleotide polymorphisms (SNPs) associated with type 2 diabetes overlap with putative endocrine pancreatic enhancers, suggesting that these SNPs modulate enhancer activity and, consequently, gene expression. We performed in vivo mosaic transgenesis assays in zebrafish to quantitatively t...

Descripción completa

Detalles Bibliográficos
Autores principales: Eufrásio, Ana, Perrod, Chiara, Ferreira, Fábio J., Duque, Marta, Galhardo, Mafalda, Bessa, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2020
Materias:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679775/
https://www.ncbi.nlm.nih.gov/pubmed/32912862
http://dx.doi.org/10.2337/db19-1049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679775/
https://www.ncbi.nlm.nih.gov/pubmed/32912862
http://dx.doi.org/10.2337/db19-1049

Ejemplares similares