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In Vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes–Associated Single Nucleotide Polymorphisms

Many single nucleotide polymorphisms (SNPs) associated with type 2 diabetes overlap with putative endocrine pancreatic enhancers, suggesting that these SNPs modulate enhancer activity and, consequently, gene expression. We performed in vivo mosaic transgenesis assays in zebrafish to quantitatively t...

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Detalles Bibliográficos
Autores principales:	Eufrásio, Ana, Perrod, Chiara, Ferreira, Fábio J., Duque, Marta, Galhardo, Mafalda, Bessa, José
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2020
Materias:	Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679775/ https://www.ncbi.nlm.nih.gov/pubmed/32912862 http://dx.doi.org/10.2337/db19-1049

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