Consensus mutagenesis approach improves the thermal stability of system x(c) (−) transporter, xCT, and enables cryo‐EM analyses

System x(c) (−) is an amino acid antiporter that imports L‐cystine into cells and exports intracellular L‐glutamate, at a 1:1 ratio. As L‐cystine is an essential precursor for glutathione synthesis, system x(c) (−) supports tumor cell growth through glutathione‐based oxidative stress resistance and...

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Detalles Bibliográficos
Autores principales: Oda, Kazumasa, Lee, Yongchan, Wiriyasermkul, Pattama, Tanaka, Yoko, Takemoto, Mizuki, Yamashita, Keitaro, Nagamori, Shushi, Nishizawa, Tomohiro, Nureki, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Full‐Length Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679960/
https://www.ncbi.nlm.nih.gov/pubmed/33016372
http://dx.doi.org/10.1002/pro.3966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679960/
https://www.ncbi.nlm.nih.gov/pubmed/33016372
http://dx.doi.org/10.1002/pro.3966

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