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Consensus mutagenesis approach improves the thermal stability of system x(c) (−) transporter, xCT, and enables cryo‐EM analyses
System x(c) (−) is an amino acid antiporter that imports L‐cystine into cells and exports intracellular L‐glutamate, at a 1:1 ratio. As L‐cystine is an essential precursor for glutathione synthesis, system x(c) (−) supports tumor cell growth through glutathione‐based oxidative stress resistance and...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679960/ https://www.ncbi.nlm.nih.gov/pubmed/33016372 http://dx.doi.org/10.1002/pro.3966 |