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Sleep characteristics and problems of 2-year-olds with Williams syndrome: relations with language and behavior

BACKGROUND: Sleep problems have been shown to have a negative impact on language development and behavior for both typically developing children and children with a range of neurodevelopmental disorders. The relation of sleep characteristics and problems to language and behavior for children with Wi...

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Autores principales: Greiner de Magalhães, Caroline, O’Brien, Louise M., Mervis, Carolyn B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679988/
https://www.ncbi.nlm.nih.gov/pubmed/33218304
http://dx.doi.org/10.1186/s11689-020-09336-z
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author Greiner de Magalhães, Caroline
O’Brien, Louise M.
Mervis, Carolyn B.
author_facet Greiner de Magalhães, Caroline
O’Brien, Louise M.
Mervis, Carolyn B.
author_sort Greiner de Magalhães, Caroline
collection PubMed
description BACKGROUND: Sleep problems have been shown to have a negative impact on language development and behavior for both typically developing children and children with a range of neurodevelopmental disorders. The relation of sleep characteristics and problems to language and behavior for children with Williams syndrome (WS) is unclear. The goal of this study was to address these relations for 2-year-olds with WS. Associations of nonverbal reasoning ability, nighttime sleep duration, and excessive daytime sleepiness with language ability and behavior problems were considered. METHOD: Ninety-six 2-year-olds with genetically confirmed classic-length WS deletions participated. Parents completed the Pediatric Sleep Questionnaire, which includes a Sleep-Related Breathing Disorder (SRBD) scale with a subscale measuring excessive daytime sleepiness, to assess sleep characteristics and problems. Parents also completed the Child Behavior Checklist (CBCL) and the MacArthur-Bates Communicative Development Inventory: Words and Sentences to assess behavior problems and expressive vocabulary, respectively. Children completed the Mullen Scales of Early Learning to measure nonverbal reasoning and language abilities. RESULTS: Parents indicated that children slept an average of 10.36 h per night (SD = 1.09, range 7.3–13.3), not differing significantly from the mean reported by Bell and Zimmerman (2010) for typically developing toddlers (p = .787). Sixteen percent of participants screened positive for SRBD and 30% for excessive daytime sleepiness. Children who screened positive for SRBD had significantly more behavior problems on all CBCL scales than children who screened negative. Children with excessive daytime sleepiness had significantly more attention/hyperactivity, stress, and externalizing problems than those who did not have daytime sleepiness. Individual differences in parent-reported nighttime sleep duration and directly measured nonverbal reasoning abilities accounted for unique variance in expressive language, receptive language, and internalizing problems. Individual differences in parent-reported daytime sleepiness accounted for unique variance in externalizing problems. CONCLUSIONS: The relations of nighttime sleep duration, positive screens for SRBD, and excessive daytime sleepiness to language and behavior in toddlers with WS parallel prior findings for typically developing toddlers. These results highlight the importance of screening young children with WS for sleep problems. Studies investigating the efficacy of behavioral strategies for improving sleep in children with WS are warranted. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s11689-020-09336-z.
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spelling pubmed-76799882020-11-23 Sleep characteristics and problems of 2-year-olds with Williams syndrome: relations with language and behavior Greiner de Magalhães, Caroline O’Brien, Louise M. Mervis, Carolyn B. J Neurodev Disord Research BACKGROUND: Sleep problems have been shown to have a negative impact on language development and behavior for both typically developing children and children with a range of neurodevelopmental disorders. The relation of sleep characteristics and problems to language and behavior for children with Williams syndrome (WS) is unclear. The goal of this study was to address these relations for 2-year-olds with WS. Associations of nonverbal reasoning ability, nighttime sleep duration, and excessive daytime sleepiness with language ability and behavior problems were considered. METHOD: Ninety-six 2-year-olds with genetically confirmed classic-length WS deletions participated. Parents completed the Pediatric Sleep Questionnaire, which includes a Sleep-Related Breathing Disorder (SRBD) scale with a subscale measuring excessive daytime sleepiness, to assess sleep characteristics and problems. Parents also completed the Child Behavior Checklist (CBCL) and the MacArthur-Bates Communicative Development Inventory: Words and Sentences to assess behavior problems and expressive vocabulary, respectively. Children completed the Mullen Scales of Early Learning to measure nonverbal reasoning and language abilities. RESULTS: Parents indicated that children slept an average of 10.36 h per night (SD = 1.09, range 7.3–13.3), not differing significantly from the mean reported by Bell and Zimmerman (2010) for typically developing toddlers (p = .787). Sixteen percent of participants screened positive for SRBD and 30% for excessive daytime sleepiness. Children who screened positive for SRBD had significantly more behavior problems on all CBCL scales than children who screened negative. Children with excessive daytime sleepiness had significantly more attention/hyperactivity, stress, and externalizing problems than those who did not have daytime sleepiness. Individual differences in parent-reported nighttime sleep duration and directly measured nonverbal reasoning abilities accounted for unique variance in expressive language, receptive language, and internalizing problems. Individual differences in parent-reported daytime sleepiness accounted for unique variance in externalizing problems. CONCLUSIONS: The relations of nighttime sleep duration, positive screens for SRBD, and excessive daytime sleepiness to language and behavior in toddlers with WS parallel prior findings for typically developing toddlers. These results highlight the importance of screening young children with WS for sleep problems. Studies investigating the efficacy of behavioral strategies for improving sleep in children with WS are warranted. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s11689-020-09336-z. BioMed Central 2020-11-20 /pmc/articles/PMC7679988/ /pubmed/33218304 http://dx.doi.org/10.1186/s11689-020-09336-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Greiner de Magalhães, Caroline
O’Brien, Louise M.
Mervis, Carolyn B.
Sleep characteristics and problems of 2-year-olds with Williams syndrome: relations with language and behavior
title Sleep characteristics and problems of 2-year-olds with Williams syndrome: relations with language and behavior
title_full Sleep characteristics and problems of 2-year-olds with Williams syndrome: relations with language and behavior
title_fullStr Sleep characteristics and problems of 2-year-olds with Williams syndrome: relations with language and behavior
title_full_unstemmed Sleep characteristics and problems of 2-year-olds with Williams syndrome: relations with language and behavior
title_short Sleep characteristics and problems of 2-year-olds with Williams syndrome: relations with language and behavior
title_sort sleep characteristics and problems of 2-year-olds with williams syndrome: relations with language and behavior
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679988/
https://www.ncbi.nlm.nih.gov/pubmed/33218304
http://dx.doi.org/10.1186/s11689-020-09336-z
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