Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities

BACKGROUND: Tight regulatory loops orchestrate commitment to B cell fate within bone marrow. Genetic lesions in this gene regulatory network underlie the emergence of the most common childhood cancer, acute lymphoblastic leukemia (ALL). The initial genetic hits, including the common translocation th...

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Detalles Bibliográficos
Autores principales: Mehtonen, Juha, Teppo, Susanna, Lahnalampi, Mari, Kokko, Aleksi, Kaukonen, Riina, Oksa, Laura, Bouvy-Liivrand, Maria, Malyukova, Alena, Mäkinen, Artturi, Laukkanen, Saara, Mäkinen, Petri I., Rounioja, Samuli, Ruusuvuori, Pekka, Sangfelt, Olle, Lund, Riikka, Lönnberg, Tapio, Lohi, Olli, Heinäniemi, Merja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679990/
https://www.ncbi.nlm.nih.gov/pubmed/33218352
http://dx.doi.org/10.1186/s13073-020-00799-2

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