COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study

Patients with COVID-19 ARDS have distinct physiological and immunological phenotypes compared to patients with non-COVID ARDS. Patients with COVID-19 ARDS (n = 32) had a significant improvement in PaO(2): FiO(2) ratio (p = 0.046) following low-dose steroid treatment, unlike patients with non-COVID A...

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Detalles Bibliográficos
Autores principales: Longobardo, Alessia, Snow, Timothy Arthur Chandos, Montanari, Cecilia, Shulman, Robert, Singer, Mervyn, Arulkumaran, Nishkantha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680030/
https://www.ncbi.nlm.nih.gov/pubmed/33260010
http://dx.doi.org/10.1016/j.jcrc.2020.11.012
Descripción
Sumario:Patients with COVID-19 ARDS have distinct physiological and immunological phenotypes compared to patients with non-COVID ARDS. Patients with COVID-19 ARDS (n = 32) had a significant improvement in PaO(2): FiO(2) ratio (p = 0.046) following low-dose steroid treatment, unlike patients with non-COVID ARDS (n = 16) (p = 0.529). Patients with COVID-19 ARDS had a greater fall in CRP compared to patients with non-COVID ARDS, albeit not statistically significant (p = 0.07). Our novel findings highlight differences in the underlying physiological and immunological phenotypes between COVID-19 and non-COVID ARDS, with implications for future ARDS studies.

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