COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study

Patients with COVID-19 ARDS have distinct physiological and immunological phenotypes compared to patients with non-COVID ARDS. Patients with COVID-19 ARDS (n = 32) had a significant improvement in PaO(2): FiO(2) ratio (p = 0.046) following low-dose steroid treatment, unlike patients with non-COVID A...

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Autores principales: Longobardo, Alessia, Snow, Timothy Arthur Chandos, Montanari, Cecilia, Shulman, Robert, Singer, Mervyn, Arulkumaran, Nishkantha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680030/
https://www.ncbi.nlm.nih.gov/pubmed/33260010
http://dx.doi.org/10.1016/j.jcrc.2020.11.012
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author Longobardo, Alessia
Snow, Timothy Arthur Chandos
Montanari, Cecilia
Shulman, Robert
Singer, Mervyn
Arulkumaran, Nishkantha
author_facet Longobardo, Alessia
Snow, Timothy Arthur Chandos
Montanari, Cecilia
Shulman, Robert
Singer, Mervyn
Arulkumaran, Nishkantha
author_sort Longobardo, Alessia
collection PubMed
description Patients with COVID-19 ARDS have distinct physiological and immunological phenotypes compared to patients with non-COVID ARDS. Patients with COVID-19 ARDS (n = 32) had a significant improvement in PaO(2): FiO(2) ratio (p = 0.046) following low-dose steroid treatment, unlike patients with non-COVID ARDS (n = 16) (p = 0.529). Patients with COVID-19 ARDS had a greater fall in CRP compared to patients with non-COVID ARDS, albeit not statistically significant (p = 0.07). Our novel findings highlight differences in the underlying physiological and immunological phenotypes between COVID-19 and non-COVID ARDS, with implications for future ARDS studies.
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spelling pubmed-76800302020-11-23 COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study Longobardo, Alessia Snow, Timothy Arthur Chandos Montanari, Cecilia Shulman, Robert Singer, Mervyn Arulkumaran, Nishkantha J Crit Care Article Patients with COVID-19 ARDS have distinct physiological and immunological phenotypes compared to patients with non-COVID ARDS. Patients with COVID-19 ARDS (n = 32) had a significant improvement in PaO(2): FiO(2) ratio (p = 0.046) following low-dose steroid treatment, unlike patients with non-COVID ARDS (n = 16) (p = 0.529). Patients with COVID-19 ARDS had a greater fall in CRP compared to patients with non-COVID ARDS, albeit not statistically significant (p = 0.07). Our novel findings highlight differences in the underlying physiological and immunological phenotypes between COVID-19 and non-COVID ARDS, with implications for future ARDS studies. Elsevier Inc. 2021-04 2020-11-21 /pmc/articles/PMC7680030/ /pubmed/33260010 http://dx.doi.org/10.1016/j.jcrc.2020.11.012 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Longobardo, Alessia
Snow, Timothy Arthur Chandos
Montanari, Cecilia
Shulman, Robert
Singer, Mervyn
Arulkumaran, Nishkantha
COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study
title COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study
title_full COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study
title_fullStr COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study
title_full_unstemmed COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study
title_short COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study
title_sort covid-19 and non-covid ards patients demonstrate a distinct response to low dose steroids- a retrospective observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680030/
https://www.ncbi.nlm.nih.gov/pubmed/33260010
http://dx.doi.org/10.1016/j.jcrc.2020.11.012
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