The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2

The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (M(pro)) and the R...

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Autores principales: Jin, Zhenming, Wang, Haofeng, Duan, Yinkai, Yang, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680044/
https://www.ncbi.nlm.nih.gov/pubmed/33288200
http://dx.doi.org/10.1016/j.bbrc.2020.10.091
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author Jin, Zhenming
Wang, Haofeng
Duan, Yinkai
Yang, Haitao
author_facet Jin, Zhenming
Wang, Haofeng
Duan, Yinkai
Yang, Haitao
author_sort Jin, Zhenming
collection PubMed
description The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (M(pro)) and the RNA-dependent RNA polymerase (RdRP), which are responsible for the viral polyprotein proteolytic process and viral genome replication and transcription, respectively, are two attractive drug targets for SARS-CoV-2. This review summarizes up-to-date progress in the structural and pharmacological aspects of those two key targets above. Different classes of inhibitors individually targeting M(pro) and RdRP are discussed, which could promote drug development to treat SARS-CoV-2 infection.
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spelling pubmed-76800442020-11-23 The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2 Jin, Zhenming Wang, Haofeng Duan, Yinkai Yang, Haitao Biochem Biophys Res Commun Article The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (M(pro)) and the RNA-dependent RNA polymerase (RdRP), which are responsible for the viral polyprotein proteolytic process and viral genome replication and transcription, respectively, are two attractive drug targets for SARS-CoV-2. This review summarizes up-to-date progress in the structural and pharmacological aspects of those two key targets above. Different classes of inhibitors individually targeting M(pro) and RdRP are discussed, which could promote drug development to treat SARS-CoV-2 infection. Elsevier Inc. 2021-01-29 2020-11-21 /pmc/articles/PMC7680044/ /pubmed/33288200 http://dx.doi.org/10.1016/j.bbrc.2020.10.091 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Jin, Zhenming
Wang, Haofeng
Duan, Yinkai
Yang, Haitao
The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2
title The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2
title_full The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2
title_fullStr The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2
title_full_unstemmed The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2
title_short The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2
title_sort main protease and rna-dependent rna polymerase are two prime targets for sars-cov-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680044/
https://www.ncbi.nlm.nih.gov/pubmed/33288200
http://dx.doi.org/10.1016/j.bbrc.2020.10.091
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