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Exploratory study of how Cognitive Multisensory Rehabilitation restores parietal operculum connectivity and improves upper limb movements in chronic stroke

Cognitive Multisensory Rehabilitation (CMR) is a promising therapy for upper limb recovery in stroke, but the brain mechanisms are unknown. We previously demonstrated that the parietal operculum (parts OP1/OP4) is activated with CMR exercises. In this exploratory study, we assessed the baseline diff...

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Autores principales: Van de Winckel, A., De Patre, D., Rigoni, M., Fiecas, M., Hendrickson, T. J., Larson, M., Jagadeesan, B. D., Mueller, B. A., Elvendahl, W., Streib, C., Ikramuddin, F., Lim, K. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680110/
https://www.ncbi.nlm.nih.gov/pubmed/33219267
http://dx.doi.org/10.1038/s41598-020-77272-y
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author Van de Winckel, A.
De Patre, D.
Rigoni, M.
Fiecas, M.
Hendrickson, T. J.
Larson, M.
Jagadeesan, B. D.
Mueller, B. A.
Elvendahl, W.
Streib, C.
Ikramuddin, F.
Lim, K. O.
author_facet Van de Winckel, A.
De Patre, D.
Rigoni, M.
Fiecas, M.
Hendrickson, T. J.
Larson, M.
Jagadeesan, B. D.
Mueller, B. A.
Elvendahl, W.
Streib, C.
Ikramuddin, F.
Lim, K. O.
author_sort Van de Winckel, A.
collection PubMed
description Cognitive Multisensory Rehabilitation (CMR) is a promising therapy for upper limb recovery in stroke, but the brain mechanisms are unknown. We previously demonstrated that the parietal operculum (parts OP1/OP4) is activated with CMR exercises. In this exploratory study, we assessed the baseline difference between OP1/OP4 functional connectivity (FC) at rest in stroke versus healthy adults to then explore whether CMR affects OP1/OP4 connectivity and sensorimotor recovery after stroke. We recruited 8 adults with chronic stroke and left hemiplegia/paresis and 22 healthy adults. Resting-state FC with the OP1/OP4 region-of-interest in the affected hemisphere was analysed before and after 6 weeks of CMR. We evaluated sensorimotor function and activities of daily life pre- and post-CMR, and at 1-year post-CMR. At baseline, we found decreased FC between the right OP1/OP4 and 34 areas distributed across all lobes in stroke versus healthy adults. After CMR, only four areas had decreased FC compared to healthy adults. Compared to baseline (pre-CMR), participants improved on motor function (MESUPES arm p = 0.02; MESUPES hand p = 0.03; MESUPES total score p = 0.006); on stereognosis (p = 0.03); and on the Frenchay Activities Index (p = 0.03) at post-CMR and at 1-year follow-up. These results suggest enhanced sensorimotor recovery post-stroke after CMR. Our results justify larger-scale studies.
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spelling pubmed-76801102020-11-24 Exploratory study of how Cognitive Multisensory Rehabilitation restores parietal operculum connectivity and improves upper limb movements in chronic stroke Van de Winckel, A. De Patre, D. Rigoni, M. Fiecas, M. Hendrickson, T. J. Larson, M. Jagadeesan, B. D. Mueller, B. A. Elvendahl, W. Streib, C. Ikramuddin, F. Lim, K. O. Sci Rep Article Cognitive Multisensory Rehabilitation (CMR) is a promising therapy for upper limb recovery in stroke, but the brain mechanisms are unknown. We previously demonstrated that the parietal operculum (parts OP1/OP4) is activated with CMR exercises. In this exploratory study, we assessed the baseline difference between OP1/OP4 functional connectivity (FC) at rest in stroke versus healthy adults to then explore whether CMR affects OP1/OP4 connectivity and sensorimotor recovery after stroke. We recruited 8 adults with chronic stroke and left hemiplegia/paresis and 22 healthy adults. Resting-state FC with the OP1/OP4 region-of-interest in the affected hemisphere was analysed before and after 6 weeks of CMR. We evaluated sensorimotor function and activities of daily life pre- and post-CMR, and at 1-year post-CMR. At baseline, we found decreased FC between the right OP1/OP4 and 34 areas distributed across all lobes in stroke versus healthy adults. After CMR, only four areas had decreased FC compared to healthy adults. Compared to baseline (pre-CMR), participants improved on motor function (MESUPES arm p = 0.02; MESUPES hand p = 0.03; MESUPES total score p = 0.006); on stereognosis (p = 0.03); and on the Frenchay Activities Index (p = 0.03) at post-CMR and at 1-year follow-up. These results suggest enhanced sensorimotor recovery post-stroke after CMR. Our results justify larger-scale studies. Nature Publishing Group UK 2020-11-20 /pmc/articles/PMC7680110/ /pubmed/33219267 http://dx.doi.org/10.1038/s41598-020-77272-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Van de Winckel, A.
De Patre, D.
Rigoni, M.
Fiecas, M.
Hendrickson, T. J.
Larson, M.
Jagadeesan, B. D.
Mueller, B. A.
Elvendahl, W.
Streib, C.
Ikramuddin, F.
Lim, K. O.
Exploratory study of how Cognitive Multisensory Rehabilitation restores parietal operculum connectivity and improves upper limb movements in chronic stroke
title Exploratory study of how Cognitive Multisensory Rehabilitation restores parietal operculum connectivity and improves upper limb movements in chronic stroke
title_full Exploratory study of how Cognitive Multisensory Rehabilitation restores parietal operculum connectivity and improves upper limb movements in chronic stroke
title_fullStr Exploratory study of how Cognitive Multisensory Rehabilitation restores parietal operculum connectivity and improves upper limb movements in chronic stroke
title_full_unstemmed Exploratory study of how Cognitive Multisensory Rehabilitation restores parietal operculum connectivity and improves upper limb movements in chronic stroke
title_short Exploratory study of how Cognitive Multisensory Rehabilitation restores parietal operculum connectivity and improves upper limb movements in chronic stroke
title_sort exploratory study of how cognitive multisensory rehabilitation restores parietal operculum connectivity and improves upper limb movements in chronic stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680110/
https://www.ncbi.nlm.nih.gov/pubmed/33219267
http://dx.doi.org/10.1038/s41598-020-77272-y
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