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Carbon Dots from Paeoniae Radix Alba Carbonisata: Hepatoprotective Effect

INTRODUCTION: The charcoal processed product of Paeoniae Radix Alba (PRA), PRA Carbonisata (PRAC), has long been used for its hepatoprotective effects. However, the material basis and mechanism of action of PRAC remain unclear. AIM: To explore the hepatoprotective effects of Paeoniae Radix Alba Carb...

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Autores principales: Zhao, Yusheng, Zhang, Yue, Kong, Hui, Zhang, Meiling, Cheng, Jinjun, Wu, Jiashu, Qu, Huihua, Zhao, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680119/
https://www.ncbi.nlm.nih.gov/pubmed/33235451
http://dx.doi.org/10.2147/IJN.S281976
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author Zhao, Yusheng
Zhang, Yue
Kong, Hui
Zhang, Meiling
Cheng, Jinjun
Wu, Jiashu
Qu, Huihua
Zhao, Yan
author_facet Zhao, Yusheng
Zhang, Yue
Kong, Hui
Zhang, Meiling
Cheng, Jinjun
Wu, Jiashu
Qu, Huihua
Zhao, Yan
author_sort Zhao, Yusheng
collection PubMed
description INTRODUCTION: The charcoal processed product of Paeoniae Radix Alba (PRA), PRA Carbonisata (PRAC), has long been used for its hepatoprotective effects. However, the material basis and mechanism of action of PRAC remain unclear. AIM: To explore the hepatoprotective effects of Paeoniae Radix Alba Carbonisata-derived carbon dots (PRAC-CDs). METHODS: PRAC-CDs were characterized using transmission electron microscopy, high-resolution transmission electron microscopy, ultraviolet, fluorescence, Fourier transform infrared and X-ray photoelectron spectroscopy, X-ray diffraction, and high-performance liquid chromatography. The hepatoprotective effect of PRAC-CDs was evaluated and confirmed using the classic carbon tetrachloride acute liver injury model. RESULTS: PRAC-CDs averaged 1.0–2.4 nm in size and exhibited a quantum yield of 5.34% at a maximum excitation wavelength of 320 nm and emission at 411 nm. PRAC-CDs can reduce the ALT and AST levels of mice with carbon tetrachloride-induced acute liver injury and have a mitigating effect on the rise in TBA and TBIL. More interestingly, PRAC-CDs can significantly reduce MDA and increase SOD levels, demonstrating that PRAC-CDs can improve the body’s ability to scavenge oxygen free radicals and inhibit free radical-induced liver cell lipid peroxidation, thereby preventing liver cell damage. CONCLUSION: These results demonstrate the remarkable hepatoprotective effects of PRAC-CDs against carbon tetrachloride-induced acute liver injury, which provide new insights into potential biomedical and healthcare applications of CDs.
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spelling pubmed-76801192020-11-23 Carbon Dots from Paeoniae Radix Alba Carbonisata: Hepatoprotective Effect Zhao, Yusheng Zhang, Yue Kong, Hui Zhang, Meiling Cheng, Jinjun Wu, Jiashu Qu, Huihua Zhao, Yan Int J Nanomedicine Original Research INTRODUCTION: The charcoal processed product of Paeoniae Radix Alba (PRA), PRA Carbonisata (PRAC), has long been used for its hepatoprotective effects. However, the material basis and mechanism of action of PRAC remain unclear. AIM: To explore the hepatoprotective effects of Paeoniae Radix Alba Carbonisata-derived carbon dots (PRAC-CDs). METHODS: PRAC-CDs were characterized using transmission electron microscopy, high-resolution transmission electron microscopy, ultraviolet, fluorescence, Fourier transform infrared and X-ray photoelectron spectroscopy, X-ray diffraction, and high-performance liquid chromatography. The hepatoprotective effect of PRAC-CDs was evaluated and confirmed using the classic carbon tetrachloride acute liver injury model. RESULTS: PRAC-CDs averaged 1.0–2.4 nm in size and exhibited a quantum yield of 5.34% at a maximum excitation wavelength of 320 nm and emission at 411 nm. PRAC-CDs can reduce the ALT and AST levels of mice with carbon tetrachloride-induced acute liver injury and have a mitigating effect on the rise in TBA and TBIL. More interestingly, PRAC-CDs can significantly reduce MDA and increase SOD levels, demonstrating that PRAC-CDs can improve the body’s ability to scavenge oxygen free radicals and inhibit free radical-induced liver cell lipid peroxidation, thereby preventing liver cell damage. CONCLUSION: These results demonstrate the remarkable hepatoprotective effects of PRAC-CDs against carbon tetrachloride-induced acute liver injury, which provide new insights into potential biomedical and healthcare applications of CDs. Dove 2020-11-17 /pmc/articles/PMC7680119/ /pubmed/33235451 http://dx.doi.org/10.2147/IJN.S281976 Text en © 2020 Zhao et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zhao, Yusheng
Zhang, Yue
Kong, Hui
Zhang, Meiling
Cheng, Jinjun
Wu, Jiashu
Qu, Huihua
Zhao, Yan
Carbon Dots from Paeoniae Radix Alba Carbonisata: Hepatoprotective Effect
title Carbon Dots from Paeoniae Radix Alba Carbonisata: Hepatoprotective Effect
title_full Carbon Dots from Paeoniae Radix Alba Carbonisata: Hepatoprotective Effect
title_fullStr Carbon Dots from Paeoniae Radix Alba Carbonisata: Hepatoprotective Effect
title_full_unstemmed Carbon Dots from Paeoniae Radix Alba Carbonisata: Hepatoprotective Effect
title_short Carbon Dots from Paeoniae Radix Alba Carbonisata: Hepatoprotective Effect
title_sort carbon dots from paeoniae radix alba carbonisata: hepatoprotective effect
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680119/
https://www.ncbi.nlm.nih.gov/pubmed/33235451
http://dx.doi.org/10.2147/IJN.S281976
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