MiR-1224-5p Activates Autophagy, Cell Invasion and Inhibits Epithelial-to-Mesenchymal Transition in Osteosarcoma Cells by Directly Targeting PLK1 Through PI3K/AKT/mTOR Signaling Pathway

BACKGROUND: Osteosarcoma (OS) is one of the most common malignant bone tumors with a poor overall prognosis. MiR-1224-5p plays an important role in cancer, but its function and mechanism in OS have not been studied. MATERIALS AND METHODS: The expression of miR-1224-5p and PLK1 was detected by qRT-PC...

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Detalles Bibliográficos
Autores principales: Jin, Bicheng, Jin, Dongfang, Zhuo, Zhaozhen, Zhang, Bo, Chen, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680192/
https://www.ncbi.nlm.nih.gov/pubmed/33235467
http://dx.doi.org/10.2147/OTT.S274451

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