Role of Therapeutic Plasma Exchange in Resolution of Hyperhemolysis in a Patient Living with HIV/AIDS (PLHA) Diagnosed with Paroxysmal Cold Haemoglobinuria: A Case Report”

Paroxysmal cold haemoglobinuria (PCH) is an acquired cause of haemolytic anaemia. It is caused by the biphasic IgG antibodies that sensitize and attach the red cells at lower temperature; detach and rebind on rewarming. Donath-Landsteiner antibody test is the diagnostic test for PCH. Management of P...

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Autores principales: Gupta, Anubhav, Chaudhary, Kiran, Bhatta, Ajay, Swain, Bishakha, Prasad, Hari, Kakkar, Brinda, Asati, Swati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680651/
https://www.ncbi.nlm.nih.gov/pubmed/33250595
http://dx.doi.org/10.1007/s12288-020-01387-5
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author Gupta, Anubhav
Chaudhary, Kiran
Bhatta, Ajay
Swain, Bishakha
Prasad, Hari
Kakkar, Brinda
Asati, Swati
author_facet Gupta, Anubhav
Chaudhary, Kiran
Bhatta, Ajay
Swain, Bishakha
Prasad, Hari
Kakkar, Brinda
Asati, Swati
author_sort Gupta, Anubhav
collection PubMed
description Paroxysmal cold haemoglobinuria (PCH) is an acquired cause of haemolytic anaemia. It is caused by the biphasic IgG antibodies that sensitize and attach the red cells at lower temperature; detach and rebind on rewarming. Donath-Landsteiner antibody test is the diagnostic test for PCH. Management of PCH mainly includes supportive care but sometimes disease becomes severe and life-threatening. We describe a similar severe and life-threatening case of PCH who was managed by plasma exchange followed by packed red cell transfusion.
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spelling pubmed-76806512020-11-23 Role of Therapeutic Plasma Exchange in Resolution of Hyperhemolysis in a Patient Living with HIV/AIDS (PLHA) Diagnosed with Paroxysmal Cold Haemoglobinuria: A Case Report” Gupta, Anubhav Chaudhary, Kiran Bhatta, Ajay Swain, Bishakha Prasad, Hari Kakkar, Brinda Asati, Swati Indian J Hematol Blood Transfus Short Communication Paroxysmal cold haemoglobinuria (PCH) is an acquired cause of haemolytic anaemia. It is caused by the biphasic IgG antibodies that sensitize and attach the red cells at lower temperature; detach and rebind on rewarming. Donath-Landsteiner antibody test is the diagnostic test for PCH. Management of PCH mainly includes supportive care but sometimes disease becomes severe and life-threatening. We describe a similar severe and life-threatening case of PCH who was managed by plasma exchange followed by packed red cell transfusion. Springer India 2020-11-22 2021-04 /pmc/articles/PMC7680651/ /pubmed/33250595 http://dx.doi.org/10.1007/s12288-020-01387-5 Text en © Indian Society of Hematology and Blood Transfusion 2020
spellingShingle Short Communication
Gupta, Anubhav
Chaudhary, Kiran
Bhatta, Ajay
Swain, Bishakha
Prasad, Hari
Kakkar, Brinda
Asati, Swati
Role of Therapeutic Plasma Exchange in Resolution of Hyperhemolysis in a Patient Living with HIV/AIDS (PLHA) Diagnosed with Paroxysmal Cold Haemoglobinuria: A Case Report”
title Role of Therapeutic Plasma Exchange in Resolution of Hyperhemolysis in a Patient Living with HIV/AIDS (PLHA) Diagnosed with Paroxysmal Cold Haemoglobinuria: A Case Report”
title_full Role of Therapeutic Plasma Exchange in Resolution of Hyperhemolysis in a Patient Living with HIV/AIDS (PLHA) Diagnosed with Paroxysmal Cold Haemoglobinuria: A Case Report”
title_fullStr Role of Therapeutic Plasma Exchange in Resolution of Hyperhemolysis in a Patient Living with HIV/AIDS (PLHA) Diagnosed with Paroxysmal Cold Haemoglobinuria: A Case Report”
title_full_unstemmed Role of Therapeutic Plasma Exchange in Resolution of Hyperhemolysis in a Patient Living with HIV/AIDS (PLHA) Diagnosed with Paroxysmal Cold Haemoglobinuria: A Case Report”
title_short Role of Therapeutic Plasma Exchange in Resolution of Hyperhemolysis in a Patient Living with HIV/AIDS (PLHA) Diagnosed with Paroxysmal Cold Haemoglobinuria: A Case Report”
title_sort role of therapeutic plasma exchange in resolution of hyperhemolysis in a patient living with hiv/aids (plha) diagnosed with paroxysmal cold haemoglobinuria: a case report”
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680651/
https://www.ncbi.nlm.nih.gov/pubmed/33250595
http://dx.doi.org/10.1007/s12288-020-01387-5
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