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A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone
Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) play important roles in bone metabolism. Smad ubiquitination regulatory factors (Smurfs) regulate TGF-β/BMP signaling via ubiquitination, resulting in degradation of signaling molecules to prevent excessive activation of TGF-β...
Autores principales: | Kushioka, Junichi, Kaito, Takashi, Okada, Rintaro, Ishiguro, Hiroyuki, Bal, Zeynep, Kodama, Joe, Chijimatsu, Ryota, Pye, Melanie, Narimatsu, Masahiro, Wrana, Jeffrey L., Inoue, Yasumichi, Ninomiya, Hiroko, Yamamoto, Shin, Saitou, Takashi, Yoshikawa, Hideki, Imamura, Takeshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680794/ https://www.ncbi.nlm.nih.gov/pubmed/33298874 http://dx.doi.org/10.1038/s41413-020-00115-z |
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