Cargando…

Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism

Heme oxygenase-1 (HO-1) is an inducible enzyme known for its anti-inflammatory, antioxidant and neuroprotective effects. However, increased expression of HO-1 during aging and age-related neurodegenerative diseases have been associated to neurotoxic ferric iron deposits. Being microglia responsible...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernández-Mendívil, Cristina, Luengo, Enrique, Trigo-Alonso, Paula, García-Magro, Nuria, Negredo, Pilar, López, Manuela G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680814/ https://www.ncbi.nlm.nih.gov/pubmed/33212416 http://dx.doi.org/10.1016/j.redox.2020.101789

Ejemplares similares

Implication of type 4 NADPH oxidase (NOX4) in tauopathy
por: Luengo, Enrique, et al.
Publicado: (2021)

Multiple Morphometric Assessment of Microglial Cells in Deafferented Spinal Trigeminal Nucleus
por: García-Magro, Nuria, et al.
Publicado: (2020)

Aging and Progression of Beta-Amyloid Pathology in Alzheimer’s Disease Correlates with Microglial Heme-Oxygenase-1 Overexpression
por: Fernández-Mendívil, Cristina, et al.
Publicado: (2020)

Modulation of mechanosensory vibrissal responses in the trigeminocervical complex by stimulation of the greater occipital nerve in a rat model of trigeminal neuropathic pain
por: García-Magro, Nuria, et al.
Publicado: (2020)

Microglia and Inhibitory Circuitry in the Medullary Dorsal Horn: Laminar and Time-Dependent Changes in a Trigeminal Model of Neuropathic Pain
por: García-Magro, Nuria, et al.
Publicado: (2021)

Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1(G93A) female mice
por: Ruiz-Ruiz, Cristina, et al.
Publicado: (2020)

Brain Iron Homeostasis: A Focus on Microglial Iron
por: Nnah, Israel C., et al.
Publicado: (2018)

Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy
por: Fernández-Albarral, José A., et al.
Publicado: (2022)

Cryptotanshinone Attenuates Inflammatory Response of Microglial Cells via the Nrf2/HO-1 Pathway
por: Zhou, Yang, et al.
Publicado: (2019)

CD22 blockade restores homeostatic microglial phagocytosis in aging brains
por: Pluvinage, John V., et al.
Publicado: (2019)

Methyl Jasmonate Protects Microglial Cells Against β-Amyloid-Induced Oxidative Stress and Inflammation via Nrf2-Dependent HO-1 Pathway
por: Li, Hua, et al.
Publicado: (2020)

Commentary: CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
por: Wei, Penghui, et al.
Publicado: (2019)

Microglial iron trafficking: new player in brain injury
por: KELEŞ, Elif, et al.
Publicado: (2022)

Clinical PET Imaging of Microglial Activation: Implications for Microglial Therapeutics in Alzheimer’s Disease
por: Shen, Zhiwei, et al.
Publicado: (2018)

Knockout of ho-1 protects the striatum from ferrous iron-induced injury in a male-specific manner in mice
por: Wang, Li-Fang, et al.
Publicado: (2016)

Menthae Herba Attenuates Neuroinflammation by Regulating CREB/Nrf2/HO-1 Pathway in BV2 Microglial Cells
por: Park, Yeo Jin, et al.
Publicado: (2022)

The Glutamatergic System in Primary Somatosensory Neurons and Its Involvement in Sensory Input-Dependent Plasticity
por: Fernández-Montoya, Julia, et al.
Publicado: (2017)

Tryptanthrin Suppresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling
por: Kwon, Young-Won, et al.
Publicado: (2017)

Fetuin-A alleviates neuroinflammation against traumatic brain injury-induced microglial necroptosis by regulating Nrf-2/HO-1 pathway
por: Zhao, Pengzhan, et al.
Publicado: (2022)

Cleistocalyx nervosum var. paniala Berry Seed Protects against TNF-α-Stimulated Neuroinflammation by Inducing HO-1 and Suppressing NF-κB Mechanism in BV-2 Microglial Cells
por: Janpaijit, Sakawrat, et al.
Publicado: (2023)

The Implications of Microglial Regulation in Neuroplasticity-Dependent Stroke Recovery
por: Qiao, Chenye, et al.
Publicado: (2023)

HO-1 and CD39: It Takes Two to Protect the Realm
por: Lee, Ghee Rye, et al.
Publicado: (2019)

Blockade of microglial Cav1.2 Ca(2+) channel exacerbates the symptoms in a Parkinson’s disease model
por: Wang, Xinshuang, et al.
Publicado: (2019)

Pharmacological blockade of cannabinoid receptor 2 signaling does not affect LPS/IFN-γ-induced microglial activation
por: Olabiyi, Bolanle Fatimat, et al.
Publicado: (2023)

Suppressive Effect of Tetrahydrocurcumin on Pseudomonas aeruginosa Lipopolysaccharide-Induced Inflammation by Suppressing JAK/STAT and Nrf2/HO-1 Pathways in Microglial Cells
por: Lin, Hui-Wen, et al.
Publicado: (2022)

Celastrol Treatment Ameliorated Acute Ischemic Stroke-Induced Brain Injury by Microglial Injury Inhibition and Nrf2/HO-1 Pathway Activations
por: Cao, Fanfan, et al.
Publicado: (2023)

Microglial Function during Glucose Deprivation: Inflammatory and Neuropsychiatric Implications
por: Churchward, Matthew A., et al.
Publicado: (2017)

Microglial Response to Aspergillus flavus and Candida albicans: Implications in Endophthalmitis
por: Gandhi, Jaishree, et al.
Publicado: (2020)

Understanding microglial diversity and implications for neuronal function in health and disease
por: De Schepper, Sebastiaan, et al.
Publicado: (2020)

Metabolic regulation of microglial phagocytosis: Implications for Alzheimer's disease therapeutics
por: Lepiarz-Raba, Izabela, et al.
Publicado: (2023)

Ho! for Baltimore!
Publicado: (1895)

α(1)-antitrypsin modulates microglial-mediated neuroinflammation and protects microglial cells from amyloid-β-induced toxicity
por: Gold, Maike, et al.
Publicado: (2014)

DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65
por: Lin, Zixuan, et al.
Publicado: (2021)

Ho riscritto la formula dell'universo
por: Valsecchi, Cristina
Publicado: (2007)

Immune Modulation by Inhibitors of the HO System
por: Fernández-Fierro, Ayleen, et al.
Publicado: (2020)

Microglial subtypes: diversity within the microglial community
por: Stratoulias, Vassilis, et al.
Publicado: (2019)

Glutamine Cooperatively Upregulates Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglial Cells through the ERK and Nrf-2/HO-1 Signaling Pathway
por: Jayasooriya, Rajapaksha Gedara Prasad Tharanga, et al.
Publicado: (2020)

Cell damage produced by magnetic fluid hyperthermia on microglial BV2 cells
por: Calatayud, M. Pilar, et al.
Publicado: (2017)

Induction of Neuronal Death by Microglial AGE-Albumin: Implications for Alzheimer’s Disease
por: Byun, Kyunghee, et al.
Publicado: (2012)

Brain Renin-Angiotensin System and Microglial Polarization: Implications for Aging and Neurodegeneration
por: Labandeira-Garcia, Jose L., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hbnabhunm36fuk5gmudbl9q30t