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MERCs. The Novel Assistant to Neurotransmission?
In neuroscience, much attention is paid to intercellular interactions, in particular, to synapses. However, many researchers do not pay due attention to the contribution of intracellular contacts to the work of intercellular interactions. Nevertheless, along with synapses, intracellular contacts als...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680918/ https://www.ncbi.nlm.nih.gov/pubmed/33240039 http://dx.doi.org/10.3389/fnins.2020.589319 |
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author | Shirokova, Olesya M. Pchelin, Pavel V. Mukhina, Irina V. |
author_facet | Shirokova, Olesya M. Pchelin, Pavel V. Mukhina, Irina V. |
author_sort | Shirokova, Olesya M. |
collection | PubMed |
description | In neuroscience, much attention is paid to intercellular interactions, in particular, to synapses. However, many researchers do not pay due attention to the contribution of intracellular contacts to the work of intercellular interactions. Nevertheless, along with synapses, intracellular contacts also have complex organization and a tremendous number of regulatory elements. Mitochondria-endoplasmic reticulum contacts (MERCs) are a specific site of interaction between the two organelles; they provide a basis for a large number of cellular functions, such as calcium homeostasis, lipid metabolism, autophagy, and apoptosis. Despite the presence of these contacts in various parts of neurons and glial cells, it is yet not known whether they fulfill the same functions. There are still many unsolved questions about the work of these intracellular contacts, and one of the most important among them is if MERCs, with their broad implication into synaptic events, can be considered the assistant to neurotransmission? |
format | Online Article Text |
id | pubmed-7680918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76809182020-11-24 MERCs. The Novel Assistant to Neurotransmission? Shirokova, Olesya M. Pchelin, Pavel V. Mukhina, Irina V. Front Neurosci Neuroscience In neuroscience, much attention is paid to intercellular interactions, in particular, to synapses. However, many researchers do not pay due attention to the contribution of intracellular contacts to the work of intercellular interactions. Nevertheless, along with synapses, intracellular contacts also have complex organization and a tremendous number of regulatory elements. Mitochondria-endoplasmic reticulum contacts (MERCs) are a specific site of interaction between the two organelles; they provide a basis for a large number of cellular functions, such as calcium homeostasis, lipid metabolism, autophagy, and apoptosis. Despite the presence of these contacts in various parts of neurons and glial cells, it is yet not known whether they fulfill the same functions. There are still many unsolved questions about the work of these intracellular contacts, and one of the most important among them is if MERCs, with their broad implication into synaptic events, can be considered the assistant to neurotransmission? Frontiers Media S.A. 2020-11-09 /pmc/articles/PMC7680918/ /pubmed/33240039 http://dx.doi.org/10.3389/fnins.2020.589319 Text en Copyright © 2020 Shirokova, Pchelin and Mukhina. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Shirokova, Olesya M. Pchelin, Pavel V. Mukhina, Irina V. MERCs. The Novel Assistant to Neurotransmission? |
title | MERCs. The Novel Assistant to Neurotransmission? |
title_full | MERCs. The Novel Assistant to Neurotransmission? |
title_fullStr | MERCs. The Novel Assistant to Neurotransmission? |
title_full_unstemmed | MERCs. The Novel Assistant to Neurotransmission? |
title_short | MERCs. The Novel Assistant to Neurotransmission? |
title_sort | mercs. the novel assistant to neurotransmission? |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680918/ https://www.ncbi.nlm.nih.gov/pubmed/33240039 http://dx.doi.org/10.3389/fnins.2020.589319 |
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