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Current perspectives on invasive nontyphoidal Salmonella disease

PURPOSE OF REVIEW: We searched PubMed for scientific literature published in the past 2 years for relevant information regarding the burden of invasive nontyphoidal Salmonella disease and host factors associated with nontyphoidal Salmonella infection and discuss current knowledge on vaccine developm...

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Autores principales: Haselbeck, Andrea H., Panzner, Ursula, Im, Justin, Baker, Stephen, Meyer, Christian G., Marks, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health, Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680934/
https://www.ncbi.nlm.nih.gov/pubmed/28731899
http://dx.doi.org/10.1097/QCO.0000000000000398
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author Haselbeck, Andrea H.
Panzner, Ursula
Im, Justin
Baker, Stephen
Meyer, Christian G.
Marks, Florian
author_facet Haselbeck, Andrea H.
Panzner, Ursula
Im, Justin
Baker, Stephen
Meyer, Christian G.
Marks, Florian
author_sort Haselbeck, Andrea H.
collection PubMed
description PURPOSE OF REVIEW: We searched PubMed for scientific literature published in the past 2 years for relevant information regarding the burden of invasive nontyphoidal Salmonella disease and host factors associated with nontyphoidal Salmonella infection and discuss current knowledge on vaccine development. The following search terms were used: Salmonella, non typhoidal/nontyphoidal, NTS, disease, bloodstream infection, invasive, sepsis/septicaemia/septicemia, bacteraemia/bacteremia, gastroenteritis, incidence, prevalence, morbidity, mortality, case fatality, host/risk factor, vaccination, and prevention/control. RECENT FINDINGS: Estimates of the global invasive nontyphoidal Salmonella disease burden have been recently updated; additional data from Africa, Asia, and Latin America are now available. New data bridge various knowledge gaps, particularly with respect to host risk factors and the geographical distribution of iNTS serovars. It has also been observed that Salmonella Typhimurium sequence type 313 is emergent in several African countries. Available data suggest that genetic variation in the sequence type 313 strain has led to increased pathogenicity and human host adaptation. A bivalent efficacious vaccine, targeting Salmonella serovars Typhimurium and Enteritidis, would significantly lower the disease burden in high-risk populations. SUMMARY: The mobilization of surveillance networks, especially in Asia and Latin America, may provide missing data regarding the invasive nontyphoidal Salmonella disease burden and their corresponding antimicrobial susceptibility profiles. Efforts and resources should be directed toward invasive nontyphoidal Salmonella disease vaccine development.
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spelling pubmed-76809342020-12-10 Current perspectives on invasive nontyphoidal Salmonella disease Haselbeck, Andrea H. Panzner, Ursula Im, Justin Baker, Stephen Meyer, Christian G. Marks, Florian Curr Opin Infect Dis Review PURPOSE OF REVIEW: We searched PubMed for scientific literature published in the past 2 years for relevant information regarding the burden of invasive nontyphoidal Salmonella disease and host factors associated with nontyphoidal Salmonella infection and discuss current knowledge on vaccine development. The following search terms were used: Salmonella, non typhoidal/nontyphoidal, NTS, disease, bloodstream infection, invasive, sepsis/septicaemia/septicemia, bacteraemia/bacteremia, gastroenteritis, incidence, prevalence, morbidity, mortality, case fatality, host/risk factor, vaccination, and prevention/control. RECENT FINDINGS: Estimates of the global invasive nontyphoidal Salmonella disease burden have been recently updated; additional data from Africa, Asia, and Latin America are now available. New data bridge various knowledge gaps, particularly with respect to host risk factors and the geographical distribution of iNTS serovars. It has also been observed that Salmonella Typhimurium sequence type 313 is emergent in several African countries. Available data suggest that genetic variation in the sequence type 313 strain has led to increased pathogenicity and human host adaptation. A bivalent efficacious vaccine, targeting Salmonella serovars Typhimurium and Enteritidis, would significantly lower the disease burden in high-risk populations. SUMMARY: The mobilization of surveillance networks, especially in Asia and Latin America, may provide missing data regarding the invasive nontyphoidal Salmonella disease burden and their corresponding antimicrobial susceptibility profiles. Efforts and resources should be directed toward invasive nontyphoidal Salmonella disease vaccine development. Wolters Kluwer Health, Inc. 2017-10-01 /pmc/articles/PMC7680934/ /pubmed/28731899 http://dx.doi.org/10.1097/QCO.0000000000000398 Text en © 2017 Wolters Kluwer Health, Inc. All rights reserved http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Haselbeck, Andrea H.
Panzner, Ursula
Im, Justin
Baker, Stephen
Meyer, Christian G.
Marks, Florian
Current perspectives on invasive nontyphoidal Salmonella disease
title Current perspectives on invasive nontyphoidal Salmonella disease
title_full Current perspectives on invasive nontyphoidal Salmonella disease
title_fullStr Current perspectives on invasive nontyphoidal Salmonella disease
title_full_unstemmed Current perspectives on invasive nontyphoidal Salmonella disease
title_short Current perspectives on invasive nontyphoidal Salmonella disease
title_sort current perspectives on invasive nontyphoidal salmonella disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680934/
https://www.ncbi.nlm.nih.gov/pubmed/28731899
http://dx.doi.org/10.1097/QCO.0000000000000398
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