Cargando…

Parkinson’s Disease Diagnosis and Severity Assessment Using Ground Reaction Forces and Neural Networks

Gait analysis plays a key role in the diagnosis of Parkinson’s Disease (PD), as patients generally exhibit abnormal gait patterns compared to healthy controls. Current diagnosis and severity assessment procedures entail manual visual examinations of motor tasks, speech, and handwriting, among numero...

Descripción completa

Detalles Bibliográficos
Autores principales: Veeraragavan, Srivardhini, Gopalai, Alpha Agape, Gouwanda, Darwin, Ahmad, Siti Anom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680965/
https://www.ncbi.nlm.nih.gov/pubmed/33240106
http://dx.doi.org/10.3389/fphys.2020.587057
_version_ 1783612541895704576
author Veeraragavan, Srivardhini
Gopalai, Alpha Agape
Gouwanda, Darwin
Ahmad, Siti Anom
author_facet Veeraragavan, Srivardhini
Gopalai, Alpha Agape
Gouwanda, Darwin
Ahmad, Siti Anom
author_sort Veeraragavan, Srivardhini
collection PubMed
description Gait analysis plays a key role in the diagnosis of Parkinson’s Disease (PD), as patients generally exhibit abnormal gait patterns compared to healthy controls. Current diagnosis and severity assessment procedures entail manual visual examinations of motor tasks, speech, and handwriting, among numerous other tests, which can vary between clinicians based on their expertise and visual observation of gait tasks. Automating gait differentiation procedure can serve as a useful tool in early diagnosis and severity assessment of PD and limits the data collection to solely walking gait. In this research, a holistic, non-intrusive method is proposed to diagnose and assess PD severity in its early and moderate stages by using only Vertical Ground Reaction Force (VGRF). From the VGRF data, gait features are extracted and selected to use as training features for the Artificial Neural Network (ANN) model to diagnose PD using cross validation. If the diagnosis is positive, another ANN model will predict their Hoehn and Yahr (H&Y) score to assess their PD severity using the same VGRF data. PD Diagnosis is achieved with a high accuracy of 97.4% using simple network architecture. Additionally, the results indicate a better performance compared to other complex machine learning models that have been researched previously. Severity Assessment is also performed on the H&Y scale with 87.1% accuracy. The results of this study show that it is plausible to use only VGRF data in diagnosing and assessing early stage Parkinson’s Disease, helping patients manage the symptoms earlier and giving them a better quality of life.
format Online
Article
Text
id pubmed-7680965
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-76809652020-11-24 Parkinson’s Disease Diagnosis and Severity Assessment Using Ground Reaction Forces and Neural Networks Veeraragavan, Srivardhini Gopalai, Alpha Agape Gouwanda, Darwin Ahmad, Siti Anom Front Physiol Physiology Gait analysis plays a key role in the diagnosis of Parkinson’s Disease (PD), as patients generally exhibit abnormal gait patterns compared to healthy controls. Current diagnosis and severity assessment procedures entail manual visual examinations of motor tasks, speech, and handwriting, among numerous other tests, which can vary between clinicians based on their expertise and visual observation of gait tasks. Automating gait differentiation procedure can serve as a useful tool in early diagnosis and severity assessment of PD and limits the data collection to solely walking gait. In this research, a holistic, non-intrusive method is proposed to diagnose and assess PD severity in its early and moderate stages by using only Vertical Ground Reaction Force (VGRF). From the VGRF data, gait features are extracted and selected to use as training features for the Artificial Neural Network (ANN) model to diagnose PD using cross validation. If the diagnosis is positive, another ANN model will predict their Hoehn and Yahr (H&Y) score to assess their PD severity using the same VGRF data. PD Diagnosis is achieved with a high accuracy of 97.4% using simple network architecture. Additionally, the results indicate a better performance compared to other complex machine learning models that have been researched previously. Severity Assessment is also performed on the H&Y scale with 87.1% accuracy. The results of this study show that it is plausible to use only VGRF data in diagnosing and assessing early stage Parkinson’s Disease, helping patients manage the symptoms earlier and giving them a better quality of life. Frontiers Media S.A. 2020-11-09 /pmc/articles/PMC7680965/ /pubmed/33240106 http://dx.doi.org/10.3389/fphys.2020.587057 Text en Copyright © 2020 Veeraragavan, Gopalai, Gouwanda and Ahmad. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Veeraragavan, Srivardhini
Gopalai, Alpha Agape
Gouwanda, Darwin
Ahmad, Siti Anom
Parkinson’s Disease Diagnosis and Severity Assessment Using Ground Reaction Forces and Neural Networks
title Parkinson’s Disease Diagnosis and Severity Assessment Using Ground Reaction Forces and Neural Networks
title_full Parkinson’s Disease Diagnosis and Severity Assessment Using Ground Reaction Forces and Neural Networks
title_fullStr Parkinson’s Disease Diagnosis and Severity Assessment Using Ground Reaction Forces and Neural Networks
title_full_unstemmed Parkinson’s Disease Diagnosis and Severity Assessment Using Ground Reaction Forces and Neural Networks
title_short Parkinson’s Disease Diagnosis and Severity Assessment Using Ground Reaction Forces and Neural Networks
title_sort parkinson’s disease diagnosis and severity assessment using ground reaction forces and neural networks
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680965/
https://www.ncbi.nlm.nih.gov/pubmed/33240106
http://dx.doi.org/10.3389/fphys.2020.587057
work_keys_str_mv AT veeraragavansrivardhini parkinsonsdiseasediagnosisandseverityassessmentusinggroundreactionforcesandneuralnetworks
AT gopalaialphaagape parkinsonsdiseasediagnosisandseverityassessmentusinggroundreactionforcesandneuralnetworks
AT gouwandadarwin parkinsonsdiseasediagnosisandseverityassessmentusinggroundreactionforcesandneuralnetworks
AT ahmadsitianom parkinsonsdiseasediagnosisandseverityassessmentusinggroundreactionforcesandneuralnetworks