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Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects

To see if variations in timing of rapamycin (Rapa), administered to middle aged mice starting at 20 months, would lead to different survival outcomes, we compared three dosing regimens. Initiation of Rapa at 42 ppm increased survival significantly in both male and female mice. Exposure to Rapa for a...

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Detalles Bibliográficos
Autores principales:	Strong, Randy, Miller, Richard A., Bogue, Molly, Fernandez, Elizabeth, Javors, Martin A., Libert, Sergiy, Marinez, Paul Anthony, Murphy, Michael P., Musi, Nicolas, Nelson, James F., Petrascheck, Michael, Reifsnyder, Peter, Richardson, Arlan, Salmon, Adam B., Macchiarini, Francesca, Harrison, David E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681050/ https://www.ncbi.nlm.nih.gov/pubmed/33145977 http://dx.doi.org/10.1111/acel.13269

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