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Regulatory feedback cycle of the insulin‐degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer’s disease

One of the major pathological hallmarks of Alzheimer´s disease (AD) is an accumulation of amyloid‐β (Aβ) in brain tissue leading to formation of toxic oligomers and senile plaques. Under physiological conditions, a tightly balanced equilibrium between Aβ‐production and ‐degradation is necessary to p...

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Detalles Bibliográficos
Autores principales:	Lauer, Anna A., Mett, Janine, Janitschke, Daniel, Thiel, Andrea, Stahlmann, Christoph P., Bachmann, Cornel M., Ritzmann, Felix, Schrul, Bianca, Müller, Ulrike C., Stein, Reuven, Riemenschneider, Matthias, Grimm, Heike S., Hartmann, Tobias, Grimm, Marcus O. W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681056/ https://www.ncbi.nlm.nih.gov/pubmed/33128835 http://dx.doi.org/10.1111/acel.13264

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