Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis

Rationale: As the central hallmark of liver fibrosis, transdifferentiation of hepatic stellate cells (HSCs), the predominant contributor to fibrogenic hepatic myofibroblast responsible for extracellular matrix (ECM) deposition, is characterized with transcriptional and epigenetic remodeling. We aime...

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Detalles Bibliográficos
Autores principales: Jiang, Yan, Xiang, Chan, Zhong, Fan, Zhang, Yang, Wang, Liyan, Zhao, Yuanyuan, Wang, Jiucun, Ding, Chen, Jin, Li, He, Fuchu, Wang, Haijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681085/
https://www.ncbi.nlm.nih.gov/pubmed/33391480
http://dx.doi.org/10.7150/thno.46360

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