Cargando…

Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions

Low back pain (LBP) is a major reason for disability, and symptomatic intervertebral disc (IVD) degeneration (IDD) contributes to roughly 40% of all LBP cases. Current treatment modalities for IDD include conservative and surgical strategies. Unfortunately, there is a significant number of patients...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kamali, Amir, Ziadlou, Reihane, Lang, Gernot, Pfannkuche, Judith, Cui, Shangbin, Li, Zhen, Richards, R. Geoff, Alini, Mauro, Grad, Sibylle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681102/ https://www.ncbi.nlm.nih.gov/pubmed/33391459 http://dx.doi.org/10.7150/thno.48987

Ejemplares similares

Transcriptional profiling of intervertebral disc in a post‐traumatic early degeneration organ culture model
por: Cui, Shangbin, et al.
Publicado: (2021)

Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration
por: Cui, Shangbin, et al.
Publicado: (2022)

Proinflammatory intervertebral disc cell and organ culture models induced by tumor necrosis factor alpha
por: Du, Jie, et al.
Publicado: (2020)

Small molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidence
por: Zhang, Penghui, et al.
Publicado: (2022)

Preclinical ex-vivo Testing of Anti-inflammatory Drugs in a Bovine Intervertebral Degenerative Disc Model
por: Li, Zhen, et al.
Publicado: (2020)

Identification and Characterization of Serum microRNAs as Biomarkers for Human Disc Degeneration: An RNA Sequencing Analysis
por: Cui, Shangbin, et al.
Publicado: (2020)

Uncovering the secretome of mesenchymal stromal cells exposed to healthy, traumatic, and degenerative intervertebral discs: a proteomic analysis
por: Wangler, Sebastian, et al.
Publicado: (2021)

One strike loading organ culture model to investigate the post-traumatic disc degenerative condition
por: Zhou, Zhiyu, et al.
Publicado: (2020)

The influence of intervertebral disc overloading on nociceptor calcium flickering
por: Gewiess, Jan, et al.
Publicado: (2023)

Anti-Inflammatory and Chondroprotective Effects of Vanillic Acid and Epimedin C in Human Osteoarthritic Chondrocytes
por: Ziadlou, Reihane, et al.
Publicado: (2020)

Direct and Intervertebral DiscMediated Sensitization of Dorsal Root Ganglion Neurons by Hypoxia and Low pH
por: Ma, Junxuan, et al.
Publicado: (2020)

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
por: Sakai, Daisuke, et al.
Publicado: (2012)

Regulation of Inflammatory Response in Human Osteoarthritic Chondrocytes by Novel Herbal Small Molecules
por: Ziadlou, Reihane, et al.
Publicado: (2019)

Isolation of high‐quality RNA from intervertebral disc tissue via pronase predigestion and tissue pulverization
por: Caprez, Stephanie, et al.
Publicado: (2018)

Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc
por: Collin, Estelle C, et al.
Publicado: (2017)

Intervertebral disc response to stem cell treatment is conditioned by disc state and cell carrier: An ex vivo study
por: Peroglio, Marianna, et al.
Publicado: (2017)

Cells and Biomaterials for Intervertebral Disc Regeneration
por: Grad, Sibylle
Publicado: (2010)

Toward the Next Generation of Spine Bioreactors: Validation of an Ex Vivo Intervertebral Disc Organ Model and Customized Specimen Holder for Multiaxial Loading
por: Šećerović, Amra, et al.
Publicado: (2022)

Animal Models of Osteochondral Defect for Testing Biomaterials
por: Meng, Xiangbo, et al.
Publicado: (2020)

Isolation and Characterisation of a Recombinant Antibody Fragment That Binds NCAM1-Expressing Intervertebral Disc Cells
por: Cunningham, Claire, et al.
Publicado: (2013)

Intervertebral disc degeneration—Current therapeutic options and challenges
por: Samanta, Ankita, et al.
Publicado: (2023)

Homing of vertebral‐delivered mesenchymal stromal cells for degenerative intervertebral discs repair – an in vivo proof‐of‐concept study
por: Schol, Jordy, et al.
Publicado: (2022)

Chemonucleolysis combined with dynamic loading for inducing degeneration in bovine caudal intervertebral discs
por: Vernengo, Andrea, et al.
Publicado: (2023)

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
por: Le Maitre, Christine Lyn, et al.
Publicado: (2007)

Degeneration of the intervertebral disc
por: Urban, Jill PG, et al.
Publicado: (2003)

Mesenchymal Stem Cell Homing Into Intervertebral Discs Enhances the Tie2-positive Progenitor Cell Population, Prevents Cell Death, and Induces a Proliferative Response
por: Wangler, Sebastian, et al.
Publicado: (2019)

A Hyaluronan and Platelet-Rich Plasma Hydrogel for Mesenchymal Stem Cell Delivery in the Intervertebral Disc: An Organ Culture Study
por: Russo, Fabrizio, et al.
Publicado: (2021)

A comprehensive tool box for large animal studies of intervertebral disc degeneration
por: Lee, Naomi N., et al.
Publicado: (2021)

Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration
por: Millward-Sadler, S Jane, et al.
Publicado: (2009)

Unique glycosignature for intervertebral disc and articular cartilage cells and tissues in immaturity and maturity
por: Collin, E. C., et al.
Publicado: (2016)

Pathomechanism of intervertebral disc degeneration
por: Oichi, Takeshi, et al.
Publicado: (2020)

Treatment of Intervertebral Disc Degeneration
por: Xin, Jingguo, et al.
Publicado: (2022)

Macrophages and Intervertebral Disc Degeneration
por: Koroth, Jinsha, et al.
Publicado: (2023)

The Immune Privilege of the Intervertebral Disc: Implications for Intervertebral Disc Degeneration Treatment
por: Sun, Zhen, et al.
Publicado: (2020)

In vivo experimental intervertebral disc degeneration induced by bleomycin in the rhesus monkey
por: Wei, Fuxin, et al.
Publicado: (2014)

Targeting mitochondrial dysfunction with small molecules in intervertebral disc aging and degeneration
por: Saberi, Morteza, et al.
Publicado: (2021)

Critical aspects and challenges for intervertebral disc repair and regeneration—Harnessing advances in tissue engineering
por: Buckley, Conor T., et al.
Publicado: (2018)

Intervertebral Disc Biology: Genetic Basis of Disc Degeneration
por: Munir, Sabrina, et al.
Publicado: (2018)

Angiogenesis in the degeneration of the lumbar intervertebral disc
por: David, Gh, et al.
Publicado: (2010)

Intervertebral disc degeneration therapies in human
por: Richardson, Stephen M
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ga5akjj1lk1cnhnrabtldm7fig