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Thrombospondin-1 is a prognostic biomarker and is correlated with tumor immune microenvironment in glioblastoma

Glioblastoma (GBM) is the most common malignant brain tumor and the most aggressive type of glioma, characterized by strong invasive potential and rapid recurrence despite severe treatment methods, such as maximal tumor resection followed by chemotherapy and radiotherapy. Thrombospondin-1 (THBS1) wa...

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Autores principales: Qi, Chunxiao, Lei, Lei, Hu, Jinqu, Wang, Gang, Liu, Jiyuan, Ou, Shaowu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681197/
https://www.ncbi.nlm.nih.gov/pubmed/33240428
http://dx.doi.org/10.3892/ol.2020.12283
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author Qi, Chunxiao
Lei, Lei
Hu, Jinqu
Wang, Gang
Liu, Jiyuan
Ou, Shaowu
author_facet Qi, Chunxiao
Lei, Lei
Hu, Jinqu
Wang, Gang
Liu, Jiyuan
Ou, Shaowu
author_sort Qi, Chunxiao
collection PubMed
description Glioblastoma (GBM) is the most common malignant brain tumor and the most aggressive type of glioma, characterized by strong invasive potential and rapid recurrence despite severe treatment methods, such as maximal tumor resection followed by chemotherapy and radiotherapy. Thrombospondin-1 (THBS1) was first discovered in platelets and subsequent studies have indicated its functions in the development of several cancers, including breast cancer, melanoma, gastric cancer, cervical cancer and GBM. However, to the best of our knowledge, the expression profiles of THBS1 in GBM subtypes remain unknown, and the underlying mechanism by which THBS1 expression is regulated, and its effect on the local immune response in GBM, remains unclear. The present study used public datasets from The Cancer Genome Atlas, the Chinese Glioma Genome Atlas, the Gene Expression Omnibus, the Ivy Glioblastoma Atlas Project, Tumor Immune Estimation Resource, Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data and the Human Protein Atlas to investigate the prognostic value of THBS1 and its expression profiles, as well as its correlation with the local immune response in GBM. The results demonstrated that THBS1 was a biomarker of the pathological malignancy of glioma, and predicted the mesenchymal subtype of GBM. Furthermore, DNA methylation of THBS1 may be an important mechanism by which THBS1 expression is regulated in GBM. The hypomethylation or overexpression of THBS1 predicted an unfavorable prognosis in patients with GBM. Additionally, THBS1 was correlated with immune and inflammatory responses in GBM. Thus, the findings of the present study provide insight into the potential value of THBS1 in the treatment of GBM.
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spelling pubmed-76811972020-11-24 Thrombospondin-1 is a prognostic biomarker and is correlated with tumor immune microenvironment in glioblastoma Qi, Chunxiao Lei, Lei Hu, Jinqu Wang, Gang Liu, Jiyuan Ou, Shaowu Oncol Lett Articles Glioblastoma (GBM) is the most common malignant brain tumor and the most aggressive type of glioma, characterized by strong invasive potential and rapid recurrence despite severe treatment methods, such as maximal tumor resection followed by chemotherapy and radiotherapy. Thrombospondin-1 (THBS1) was first discovered in platelets and subsequent studies have indicated its functions in the development of several cancers, including breast cancer, melanoma, gastric cancer, cervical cancer and GBM. However, to the best of our knowledge, the expression profiles of THBS1 in GBM subtypes remain unknown, and the underlying mechanism by which THBS1 expression is regulated, and its effect on the local immune response in GBM, remains unclear. The present study used public datasets from The Cancer Genome Atlas, the Chinese Glioma Genome Atlas, the Gene Expression Omnibus, the Ivy Glioblastoma Atlas Project, Tumor Immune Estimation Resource, Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data and the Human Protein Atlas to investigate the prognostic value of THBS1 and its expression profiles, as well as its correlation with the local immune response in GBM. The results demonstrated that THBS1 was a biomarker of the pathological malignancy of glioma, and predicted the mesenchymal subtype of GBM. Furthermore, DNA methylation of THBS1 may be an important mechanism by which THBS1 expression is regulated in GBM. The hypomethylation or overexpression of THBS1 predicted an unfavorable prognosis in patients with GBM. Additionally, THBS1 was correlated with immune and inflammatory responses in GBM. Thus, the findings of the present study provide insight into the potential value of THBS1 in the treatment of GBM. D.A. Spandidos 2021-01 2020-11-09 /pmc/articles/PMC7681197/ /pubmed/33240428 http://dx.doi.org/10.3892/ol.2020.12283 Text en Copyright: © Qi et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Qi, Chunxiao
Lei, Lei
Hu, Jinqu
Wang, Gang
Liu, Jiyuan
Ou, Shaowu
Thrombospondin-1 is a prognostic biomarker and is correlated with tumor immune microenvironment in glioblastoma
title Thrombospondin-1 is a prognostic biomarker and is correlated with tumor immune microenvironment in glioblastoma
title_full Thrombospondin-1 is a prognostic biomarker and is correlated with tumor immune microenvironment in glioblastoma
title_fullStr Thrombospondin-1 is a prognostic biomarker and is correlated with tumor immune microenvironment in glioblastoma
title_full_unstemmed Thrombospondin-1 is a prognostic biomarker and is correlated with tumor immune microenvironment in glioblastoma
title_short Thrombospondin-1 is a prognostic biomarker and is correlated with tumor immune microenvironment in glioblastoma
title_sort thrombospondin-1 is a prognostic biomarker and is correlated with tumor immune microenvironment in glioblastoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681197/
https://www.ncbi.nlm.nih.gov/pubmed/33240428
http://dx.doi.org/10.3892/ol.2020.12283
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