Genotype imputation and variability in polygenic risk score estimation

BACKGROUND: Polygenic risk scores (PRSs) are a summarization of an individual’s genetic risk for a disease or trait. These scores are being generated in research and commercial settings to study how they may be used to guide healthcare decisions. PRSs should be updated as genetic knowledgebases impr...

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Detalles Bibliográficos
Autores principales: Chen, Shang-Fu, Dias, Raquel, Evans, Doug, Salfati, Elias L., Liu, Shuchen, Wineinger, Nathan E., Torkamani, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682022/
https://www.ncbi.nlm.nih.gov/pubmed/33225976
http://dx.doi.org/10.1186/s13073-020-00801-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682022/
https://www.ncbi.nlm.nih.gov/pubmed/33225976
http://dx.doi.org/10.1186/s13073-020-00801-x

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