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The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior

BACKGROUND: The regulation of protein synthesis is a critical step in gene expression, and its dysfunction is implicated in autism spectrum disorder (ASD). The eIF4E homologous protein (4EHP, also termed eIF4E2) binds to the mRNA 5′ cap to repress translation. The stability of 4EHP is maintained thr...

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Detalles Bibliográficos
Autores principales:	Wiebe, Shane, Meng, Xiang Qi, Kim, Sung-Hoon, Zhang, Xu, Lacaille, Jean-Claude, Aguilar-Valles, Argel, Sonenberg, Nahum
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682028/ https://www.ncbi.nlm.nih.gov/pubmed/33225984 http://dx.doi.org/10.1186/s13229-020-00394-7

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