Unveiling role of sphingosine-1-phosphate receptor 2 as a brake of epithelial stem cell proliferation and a tumor suppressor in colorectal cancer

BACKGROUND: Sphingosine-1-phosphate receptor 2 (S1PR2) mediates pleiotropic functions encompassing cell proliferation, survival, and migration, which become collectively de-regulated in cancer. Information on whether S1PR2 participates in colorectal carcinogenesis/cancer is scanty, and we set out to...

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Detalles Bibliográficos
Autores principales: Petti, Luciana, Rizzo, Giulia, Rubbino, Federica, Elangovan, Sudharshan, Colombo, Piergiuseppe, Restelli, Silvia, Piontini, Andrea, Arena, Vincenzo, Carvello, Michele, Romano, Barbara, Cavalleri, Tommaso, Anselmo, Achille, Ungaro, Federica, D’Alessio, Silvia, Spinelli, Antonino, Stifter, Sanja, Grizzi, Fabio, Sgambato, Alessandro, Danese, Silvio, Laghi, Luigi, Malesci, Alberto, Vetrano, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682101/
https://www.ncbi.nlm.nih.gov/pubmed/33225975
http://dx.doi.org/10.1186/s13046-020-01740-6

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