Cargando…

Distance metrics for ranked evolutionary trees

Genealogical tree modeling is essential for estimating evolutionary parameters in population genetics and phylogenetics. Recent mathematical results concerning ranked genealogies without leaf labels unlock opportunities in the analysis of evolutionary trees. In particular, comparisons between ranked...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Jaehee, Rosenberg, Noah A., Palacios, Julia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682335/
https://www.ncbi.nlm.nih.gov/pubmed/33139566
http://dx.doi.org/10.1073/pnas.1922851117
_version_ 1783612677850923008
author Kim, Jaehee
Rosenberg, Noah A.
Palacios, Julia A.
author_facet Kim, Jaehee
Rosenberg, Noah A.
Palacios, Julia A.
author_sort Kim, Jaehee
collection PubMed
description Genealogical tree modeling is essential for estimating evolutionary parameters in population genetics and phylogenetics. Recent mathematical results concerning ranked genealogies without leaf labels unlock opportunities in the analysis of evolutionary trees. In particular, comparisons between ranked genealogies facilitate the study of evolutionary processes of different organisms sampled at multiple time periods. We propose metrics on ranked tree shapes and ranked genealogies for lineages isochronously and heterochronously sampled. Our proposed tree metrics make it possible to conduct statistical analyses of ranked tree shapes and timed ranked tree shapes or ranked genealogies. Such analyses allow us to assess differences in tree distributions, quantify estimation uncertainty, and summarize tree distributions. We show the utility of our metrics via simulations and an application in infectious diseases.
format Online
Article
Text
id pubmed-7682335
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher National Academy of Sciences
record_format MEDLINE/PubMed
spelling pubmed-76823352020-12-01 Distance metrics for ranked evolutionary trees Kim, Jaehee Rosenberg, Noah A. Palacios, Julia A. Proc Natl Acad Sci U S A Biological Sciences Genealogical tree modeling is essential for estimating evolutionary parameters in population genetics and phylogenetics. Recent mathematical results concerning ranked genealogies without leaf labels unlock opportunities in the analysis of evolutionary trees. In particular, comparisons between ranked genealogies facilitate the study of evolutionary processes of different organisms sampled at multiple time periods. We propose metrics on ranked tree shapes and ranked genealogies for lineages isochronously and heterochronously sampled. Our proposed tree metrics make it possible to conduct statistical analyses of ranked tree shapes and timed ranked tree shapes or ranked genealogies. Such analyses allow us to assess differences in tree distributions, quantify estimation uncertainty, and summarize tree distributions. We show the utility of our metrics via simulations and an application in infectious diseases. National Academy of Sciences 2020-11-17 2020-11-02 /pmc/articles/PMC7682335/ /pubmed/33139566 http://dx.doi.org/10.1073/pnas.1922851117 Text en Copyright © 2020 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Kim, Jaehee
Rosenberg, Noah A.
Palacios, Julia A.
Distance metrics for ranked evolutionary trees
title Distance metrics for ranked evolutionary trees
title_full Distance metrics for ranked evolutionary trees
title_fullStr Distance metrics for ranked evolutionary trees
title_full_unstemmed Distance metrics for ranked evolutionary trees
title_short Distance metrics for ranked evolutionary trees
title_sort distance metrics for ranked evolutionary trees
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682335/
https://www.ncbi.nlm.nih.gov/pubmed/33139566
http://dx.doi.org/10.1073/pnas.1922851117
work_keys_str_mv AT kimjaehee distancemetricsforrankedevolutionarytrees
AT rosenbergnoaha distancemetricsforrankedevolutionarytrees
AT palaciosjuliaa distancemetricsforrankedevolutionarytrees