ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation

Endometriosis affects 1 in 10 women and is characterized by the presence of abnormal endometrium at ectopic sites. ARID1A mutations are observed in deeply invasive forms of the disease, often correlating with malignancy. To identify epigenetic dependencies driving invasion, we use an unbiased approa...

Descripción completa

Detalles Bibliográficos
Autores principales: Wilson, Mike R., Reske, Jake J., Holladay, Jeanne, Neupane, Subechhya, Ngo, Julie, Cuthrell, Nina, Wegener, Marc, Rhodes, Mary, Adams, Marie, Sheridan, Rachael, Hostetter, Galen, Alotaibi, Fahad T., Yong, Paul J., Anglesio, Michael S., Lessey, Bruce A., Leach, Richard E., Teixeira, Jose M., Missmer, Stacey A., Fazleabas, Asgerally T., Chandler, Ronald L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682620/
https://www.ncbi.nlm.nih.gov/pubmed/33176148
http://dx.doi.org/10.1016/j.celrep.2020.108366

Ejemplares similares

Ejemplares similares