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Treatable traits qualifying for nonpharmacological interventions in COPD patients upon first referral to a pulmonologist: the COPD sTRAITosphere

INTRODUCTION: The present study assessed the prevalence of nine treatable traits (TTs) pinpointing nonpharmacological interventions in patients with COPD upon first referral to a pulmonologist, how these TTs co-occurred and whether and to what extent the TTs increased the odds having a severely impa...

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Autores principales: van ’t Hul, Alex J., Koolen, Eleonore H., Antons, Jeanine C., de Man, Marianne, Djamin, Remco S., in ’t Veen, Johannes C.C.M., Simons, Sami O., van den Heuvel, Michel, van den Borst, Bram, Spruit, Martijn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682701/
https://www.ncbi.nlm.nih.gov/pubmed/33263050
http://dx.doi.org/10.1183/23120541.00438-2020
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author van ’t Hul, Alex J.
Koolen, Eleonore H.
Antons, Jeanine C.
de Man, Marianne
Djamin, Remco S.
in ’t Veen, Johannes C.C.M.
Simons, Sami O.
van den Heuvel, Michel
van den Borst, Bram
Spruit, Martijn A.
author_facet van ’t Hul, Alex J.
Koolen, Eleonore H.
Antons, Jeanine C.
de Man, Marianne
Djamin, Remco S.
in ’t Veen, Johannes C.C.M.
Simons, Sami O.
van den Heuvel, Michel
van den Borst, Bram
Spruit, Martijn A.
author_sort van ’t Hul, Alex J.
collection PubMed
description INTRODUCTION: The present study assessed the prevalence of nine treatable traits (TTs) pinpointing nonpharmacological interventions in patients with COPD upon first referral to a pulmonologist, how these TTs co-occurred and whether and to what extent the TTs increased the odds having a severely impaired health status. METHODS: Data were collected from a sample of 402 COPD patients. A second sample of 381 patients with COPD was used for validation. Nine TTs were assessed: current smoking status, activity-related dyspnoea, frequent exacerbations <12 months, severe fatigue, depressed mood, poor physical capacity, low physical activity, poor nutritional status and a low level of self-management activation. For each TT the odds ratio (OR) of having a severe health status impairment was calculated. Furthermore, a graphic representation was created, the COPD sTRAITosphere, to visualise TTs prevalence and OR. RESULTS: On average 3.9±2.0 TTs per patient were observed. These TTs occurred relatively independently of each other and coexisted in 151 unique combinations. A significant positive correlation was found between the number of TTs and Clinical COPD Questionnaire total score (r=0.58; p<0.001). Patients with severe fatigue (OR: 8.8), severe activity-related dyspnoea (OR: 5.8) or depressed mood (OR: 4.2) had the highest likelihood of having a severely impaired health status. The validation sample corroborated these findings. CONCLUSIONS: Upon first referral to a pulmonologist, COPD patients show multiple TTs indicating them to several nonpharmacological interventions. These TTs coexist in many different combinations, are relatively independent and increase the likelihood of having a severely impaired health status.
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spelling pubmed-76827012020-11-30 Treatable traits qualifying for nonpharmacological interventions in COPD patients upon first referral to a pulmonologist: the COPD sTRAITosphere van ’t Hul, Alex J. Koolen, Eleonore H. Antons, Jeanine C. de Man, Marianne Djamin, Remco S. in ’t Veen, Johannes C.C.M. Simons, Sami O. van den Heuvel, Michel van den Borst, Bram Spruit, Martijn A. ERJ Open Res Original Articles INTRODUCTION: The present study assessed the prevalence of nine treatable traits (TTs) pinpointing nonpharmacological interventions in patients with COPD upon first referral to a pulmonologist, how these TTs co-occurred and whether and to what extent the TTs increased the odds having a severely impaired health status. METHODS: Data were collected from a sample of 402 COPD patients. A second sample of 381 patients with COPD was used for validation. Nine TTs were assessed: current smoking status, activity-related dyspnoea, frequent exacerbations <12 months, severe fatigue, depressed mood, poor physical capacity, low physical activity, poor nutritional status and a low level of self-management activation. For each TT the odds ratio (OR) of having a severe health status impairment was calculated. Furthermore, a graphic representation was created, the COPD sTRAITosphere, to visualise TTs prevalence and OR. RESULTS: On average 3.9±2.0 TTs per patient were observed. These TTs occurred relatively independently of each other and coexisted in 151 unique combinations. A significant positive correlation was found between the number of TTs and Clinical COPD Questionnaire total score (r=0.58; p<0.001). Patients with severe fatigue (OR: 8.8), severe activity-related dyspnoea (OR: 5.8) or depressed mood (OR: 4.2) had the highest likelihood of having a severely impaired health status. The validation sample corroborated these findings. CONCLUSIONS: Upon first referral to a pulmonologist, COPD patients show multiple TTs indicating them to several nonpharmacological interventions. These TTs coexist in many different combinations, are relatively independent and increase the likelihood of having a severely impaired health status. European Respiratory Society 2020-11-02 /pmc/articles/PMC7682701/ /pubmed/33263050 http://dx.doi.org/10.1183/23120541.00438-2020 Text en Copyright ©ERS 2020 http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Original Articles
van ’t Hul, Alex J.
Koolen, Eleonore H.
Antons, Jeanine C.
de Man, Marianne
Djamin, Remco S.
in ’t Veen, Johannes C.C.M.
Simons, Sami O.
van den Heuvel, Michel
van den Borst, Bram
Spruit, Martijn A.
Treatable traits qualifying for nonpharmacological interventions in COPD patients upon first referral to a pulmonologist: the COPD sTRAITosphere
title Treatable traits qualifying for nonpharmacological interventions in COPD patients upon first referral to a pulmonologist: the COPD sTRAITosphere
title_full Treatable traits qualifying for nonpharmacological interventions in COPD patients upon first referral to a pulmonologist: the COPD sTRAITosphere
title_fullStr Treatable traits qualifying for nonpharmacological interventions in COPD patients upon first referral to a pulmonologist: the COPD sTRAITosphere
title_full_unstemmed Treatable traits qualifying for nonpharmacological interventions in COPD patients upon first referral to a pulmonologist: the COPD sTRAITosphere
title_short Treatable traits qualifying for nonpharmacological interventions in COPD patients upon first referral to a pulmonologist: the COPD sTRAITosphere
title_sort treatable traits qualifying for nonpharmacological interventions in copd patients upon first referral to a pulmonologist: the copd straitosphere
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682701/
https://www.ncbi.nlm.nih.gov/pubmed/33263050
http://dx.doi.org/10.1183/23120541.00438-2020
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