CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin

The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https://bit.ly/32SeisO

Detalles Bibliográficos
Autores principales: Keir, Holly R., Richardson, Hollian, Fillmore, Christina, Shoemark, Amelia, Lazaar, Aili L., Miller, Bruce E., Tal-Singer, Ruth, Chalmers, James D., Mohan, Divya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2020
Materias:
Original Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682717/
https://www.ncbi.nlm.nih.gov/pubmed/33263062
http://dx.doi.org/10.1183/23120541.00583-2020
_version_ 1783612735885410304
author Keir, Holly R.
Richardson, Hollian
Fillmore, Christina
Shoemark, Amelia
Lazaar, Aili L.
Miller, Bruce E.
Tal-Singer, Ruth
Chalmers, James D.
Mohan, Divya
author_facet Keir, Holly R.
Richardson, Hollian
Fillmore, Christina
Shoemark, Amelia
Lazaar, Aili L.
Miller, Bruce E.
Tal-Singer, Ruth
Chalmers, James D.
Mohan, Divya
author_sort Keir, Holly R.
collection PubMed
description The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https://bit.ly/32SeisO
format Online
Article
Text
id pubmed-7682717
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher European Respiratory Society
record_format MEDLINE/PubMed
spelling pubmed-76827172020-11-30 CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin Keir, Holly R. Richardson, Hollian Fillmore, Christina Shoemark, Amelia Lazaar, Aili L. Miller, Bruce E. Tal-Singer, Ruth Chalmers, James D. Mohan, Divya ERJ Open Res Original Research Letters The implications of these findings are significant for development of CXCR2 antagonists and other mechanisms targeting neutrophil activation or NETosis, suggesting that IL-8-dependent mechanisms will only work in a subset of COPD patients https://bit.ly/32SeisO European Respiratory Society 2020-11-10 /pmc/articles/PMC7682717/ /pubmed/33263062 http://dx.doi.org/10.1183/23120541.00583-2020 Text en Copyright ©ERS 2020 http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Original Research Letters
Keir, Holly R.
Richardson, Hollian
Fillmore, Christina
Shoemark, Amelia
Lazaar, Aili L.
Miller, Bruce E.
Tal-Singer, Ruth
Chalmers, James D.
Mohan, Divya
CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin
title CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin
title_full CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin
title_fullStr CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin
title_full_unstemmed CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin
title_short CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin
title_sort cxcl-8-dependent and -independent neutrophil activation in copd: experiences from a pilot study of the cxcr2 antagonist danirixin
topic Original Research Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682717/
https://www.ncbi.nlm.nih.gov/pubmed/33263062
http://dx.doi.org/10.1183/23120541.00583-2020
work_keys_str_mv AT keirhollyr cxcl8dependentandindependentneutrophilactivationincopdexperiencesfromapilotstudyofthecxcr2antagonistdanirixin
AT richardsonhollian cxcl8dependentandindependentneutrophilactivationincopdexperiencesfromapilotstudyofthecxcr2antagonistdanirixin
AT fillmorechristina cxcl8dependentandindependentneutrophilactivationincopdexperiencesfromapilotstudyofthecxcr2antagonistdanirixin
AT shoemarkamelia cxcl8dependentandindependentneutrophilactivationincopdexperiencesfromapilotstudyofthecxcr2antagonistdanirixin
AT lazaarailil cxcl8dependentandindependentneutrophilactivationincopdexperiencesfromapilotstudyofthecxcr2antagonistdanirixin
AT millerbrucee cxcl8dependentandindependentneutrophilactivationincopdexperiencesfromapilotstudyofthecxcr2antagonistdanirixin
AT talsingerruth cxcl8dependentandindependentneutrophilactivationincopdexperiencesfromapilotstudyofthecxcr2antagonistdanirixin
AT chalmersjamesd cxcl8dependentandindependentneutrophilactivationincopdexperiencesfromapilotstudyofthecxcr2antagonistdanirixin
AT mohandivya cxcl8dependentandindependentneutrophilactivationincopdexperiencesfromapilotstudyofthecxcr2antagonistdanirixin

Ejemplares similares