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The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk
BACKGROUND: The goal of this study was to assess the oxidative stress status through the values of antioxidant defense parameters: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status (TAS), as well as cardiovascular risk factors (total ch...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society of Medical Biochemists of Serbia, Belgrade
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682846/ https://www.ncbi.nlm.nih.gov/pubmed/33269023 http://dx.doi.org/10.2478/jomb-2019-0051 |
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author | Čolak, Emina Pap, Dragana Nikolić, Ljubinka Vicković, Sanja |
author_facet | Čolak, Emina Pap, Dragana Nikolić, Ljubinka Vicković, Sanja |
author_sort | Čolak, Emina |
collection | PubMed |
description | BACKGROUND: The goal of this study was to assess the oxidative stress status through the values of antioxidant defense parameters: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status (TAS), as well as cardiovascular risk factors (total cholesterol, LDL-cholesterol, VLDL-cholesterol, non-HDL-cholesterol and triglycerides), anthropometric parameters (Body mass index-BMI, waist circumference-WC, hipp circumferemce-HC, waist-to-hipp ratio-WHR and inflammatory markers (high sensitive C-reactive protein) in a group of obese adolescents. METHODS: A total of 238 students of both sexes, age of 22.32 ± 1.85 yr. were included in the study. According to the values of BMI lower and higher than 25 kg/m2 and WC higher and lower than 94 cm (males)/80 cm (females) the tested group of students was divided into 2 subgroups: Group 1 (increased risk for CVD) and Group 2 (lower risk for CVD). RESULTS: Significantly reduced SOD and GPx with increased GR, TAS, inflammatory and lipoprotein parameters were obtained in Group 1 compared to Group 2. Significant positive association of hsCRP (OR:1.41; 95%CI 1.08-1.83; P=0.007), TAS (OR:827.2; 95%CI 19.27-35498; P=0.007) and GR (OR:1.13; 95%CI 1.05-1.21; P=0.002) and negative association of GPx (OR:0.97; 95%CI 0.94-1.003; P=0.043) and HDL-cholesterol (OR:0.41; 95%CI 0.176-0.963; P=0.0014) with cardiovascular risk factors were found in obese students. According to the ROC analysis GR>44.8 U/L, TAS>1.35 mmol/L, hsCRP>1.71 mg/L and HDL-cholesterol <1.13 mmol/L have sufficient predictive ability for cardiovascular disease in obese students. CONCLUSIONS: Significant association of antioxidant defense parameters with anthropometric, lipid and inflammatory markers in obese students with increased cardiovascular risk suggest that screening of these parameters is necessary and highly recommended. |
format | Online Article Text |
id | pubmed-7682846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Society of Medical Biochemists of Serbia, Belgrade |
record_format | MEDLINE/PubMed |
spelling | pubmed-76828462020-12-01 The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk Čolak, Emina Pap, Dragana Nikolić, Ljubinka Vicković, Sanja J Med Biochem Original Paper BACKGROUND: The goal of this study was to assess the oxidative stress status through the values of antioxidant defense parameters: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status (TAS), as well as cardiovascular risk factors (total cholesterol, LDL-cholesterol, VLDL-cholesterol, non-HDL-cholesterol and triglycerides), anthropometric parameters (Body mass index-BMI, waist circumference-WC, hipp circumferemce-HC, waist-to-hipp ratio-WHR and inflammatory markers (high sensitive C-reactive protein) in a group of obese adolescents. METHODS: A total of 238 students of both sexes, age of 22.32 ± 1.85 yr. were included in the study. According to the values of BMI lower and higher than 25 kg/m2 and WC higher and lower than 94 cm (males)/80 cm (females) the tested group of students was divided into 2 subgroups: Group 1 (increased risk for CVD) and Group 2 (lower risk for CVD). RESULTS: Significantly reduced SOD and GPx with increased GR, TAS, inflammatory and lipoprotein parameters were obtained in Group 1 compared to Group 2. Significant positive association of hsCRP (OR:1.41; 95%CI 1.08-1.83; P=0.007), TAS (OR:827.2; 95%CI 19.27-35498; P=0.007) and GR (OR:1.13; 95%CI 1.05-1.21; P=0.002) and negative association of GPx (OR:0.97; 95%CI 0.94-1.003; P=0.043) and HDL-cholesterol (OR:0.41; 95%CI 0.176-0.963; P=0.0014) with cardiovascular risk factors were found in obese students. According to the ROC analysis GR>44.8 U/L, TAS>1.35 mmol/L, hsCRP>1.71 mg/L and HDL-cholesterol <1.13 mmol/L have sufficient predictive ability for cardiovascular disease in obese students. CONCLUSIONS: Significant association of antioxidant defense parameters with anthropometric, lipid and inflammatory markers in obese students with increased cardiovascular risk suggest that screening of these parameters is necessary and highly recommended. Society of Medical Biochemists of Serbia, Belgrade 2020-09-02 2020-09-02 /pmc/articles/PMC7682846/ /pubmed/33269023 http://dx.doi.org/10.2478/jomb-2019-0051 Text en 2020 Emina Čolak, Dragana Pap, Ljubinka Nikolić, Sanja Vicković, published by CEON/CEES https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License. |
spellingShingle | Original Paper Čolak, Emina Pap, Dragana Nikolić, Ljubinka Vicković, Sanja The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk |
title | The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk |
title_full | The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk |
title_fullStr | The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk |
title_full_unstemmed | The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk |
title_short | The impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk |
title_sort | impact of obesity to antioxidant defense parameters in adolescents with increased cardiovascular risk |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682846/ https://www.ncbi.nlm.nih.gov/pubmed/33269023 http://dx.doi.org/10.2478/jomb-2019-0051 |
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