CD4 T Cell Metabolism Is a Major Contributor of HIV Infectivity and Reservoir Persistence

HIV infection is characterized by elevated glycolytic metabolism in CD4 T cells. In their recent study, Valle-Casuso et al. demonstrated that both increased glucose utilization and glutamine metabolism are essential for HIV infectivity and replication in CD4 T cells. Here, we discuss the broader imp...

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Detalles Bibliográficos
Autores principales: Taylor, Harry E., Palmer, Clovis S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682929/
https://www.ncbi.nlm.nih.gov/pubmed/33235814
http://dx.doi.org/10.20900/immunometab20200005
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author Taylor, Harry E.
Palmer, Clovis S.
author_facet Taylor, Harry E.
Palmer, Clovis S.
author_sort Taylor, Harry E.
collection PubMed
description HIV infection is characterized by elevated glycolytic metabolism in CD4 T cells. In their recent study, Valle-Casuso et al. demonstrated that both increased glucose utilization and glutamine metabolism are essential for HIV infectivity and replication in CD4 T cells. Here, we discuss the broader implications of immunometabolism in studies of HIV persistence and their potential to inform new treatment and curative strategies.
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spelling pubmed-76829292020-11-23 CD4 T Cell Metabolism Is a Major Contributor of HIV Infectivity and Reservoir Persistence Taylor, Harry E. Palmer, Clovis S. Immunometabolism Article HIV infection is characterized by elevated glycolytic metabolism in CD4 T cells. In their recent study, Valle-Casuso et al. demonstrated that both increased glucose utilization and glutamine metabolism are essential for HIV infectivity and replication in CD4 T cells. Here, we discuss the broader implications of immunometabolism in studies of HIV persistence and their potential to inform new treatment and curative strategies. 2020-01-10 2020 /pmc/articles/PMC7682929/ /pubmed/33235814 http://dx.doi.org/10.20900/immunometab20200005 Text en http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 International License.
spellingShingle Article
Taylor, Harry E.
Palmer, Clovis S.
CD4 T Cell Metabolism Is a Major Contributor of HIV Infectivity and Reservoir Persistence
title CD4 T Cell Metabolism Is a Major Contributor of HIV Infectivity and Reservoir Persistence
title_full CD4 T Cell Metabolism Is a Major Contributor of HIV Infectivity and Reservoir Persistence
title_fullStr CD4 T Cell Metabolism Is a Major Contributor of HIV Infectivity and Reservoir Persistence
title_full_unstemmed CD4 T Cell Metabolism Is a Major Contributor of HIV Infectivity and Reservoir Persistence
title_short CD4 T Cell Metabolism Is a Major Contributor of HIV Infectivity and Reservoir Persistence
title_sort cd4 t cell metabolism is a major contributor of hiv infectivity and reservoir persistence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682929/
https://www.ncbi.nlm.nih.gov/pubmed/33235814
http://dx.doi.org/10.20900/immunometab20200005
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