Cytokine storm of a different flavour: The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak

Here we present a case series of three patients with COVID-19 (coronavirus disease 2019) who had a cytokine panel that revealed elevation of interleukin-6 (IL-6) but normal levels of interleukin-10 (IL-10), interferon-gamma (INF-γ) and interleukin-8 (IL-8), in contrast to the cytokine signature desc...

Descripción completa

Detalles Bibliográficos
Autores principales: Griffin, Daniel O., Jensen, Alexandra, Khan, Mushmoom, Chin, Jessica, Chin, Kelly, Saad, Jennifer, Parnell, Ryan, Awwad, Christopher, Patel, Darshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682938/
https://www.ncbi.nlm.nih.gov/pubmed/33242672
http://dx.doi.org/10.1016/j.jgar.2020.11.005
_version_ 1783612775456571392
author Griffin, Daniel O.
Jensen, Alexandra
Khan, Mushmoom
Chin, Jessica
Chin, Kelly
Saad, Jennifer
Parnell, Ryan
Awwad, Christopher
Patel, Darshan
author_facet Griffin, Daniel O.
Jensen, Alexandra
Khan, Mushmoom
Chin, Jessica
Chin, Kelly
Saad, Jennifer
Parnell, Ryan
Awwad, Christopher
Patel, Darshan
author_sort Griffin, Daniel O.
collection PubMed
description Here we present a case series of three patients with COVID-19 (coronavirus disease 2019) who had a cytokine panel that revealed elevation of interleukin-6 (IL-6) but normal levels of interleukin-10 (IL-10), interferon-gamma (INF-γ) and interleukin-8 (IL-8), in contrast to the cytokine signature described in severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). We also documented evidence of a compromised T-cell IFN-γ response in two of these patients.
format Online
Article
Text
id pubmed-7682938
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.
record_format MEDLINE/PubMed
spelling pubmed-76829382020-11-24 Cytokine storm of a different flavour: The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak Griffin, Daniel O. Jensen, Alexandra Khan, Mushmoom Chin, Jessica Chin, Kelly Saad, Jennifer Parnell, Ryan Awwad, Christopher Patel, Darshan J Glob Antimicrob Resist Short Communication Here we present a case series of three patients with COVID-19 (coronavirus disease 2019) who had a cytokine panel that revealed elevation of interleukin-6 (IL-6) but normal levels of interleukin-10 (IL-10), interferon-gamma (INF-γ) and interleukin-8 (IL-8), in contrast to the cytokine signature described in severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). We also documented evidence of a compromised T-cell IFN-γ response in two of these patients. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. 2021-03 2020-11-23 /pmc/articles/PMC7682938/ /pubmed/33242672 http://dx.doi.org/10.1016/j.jgar.2020.11.005 Text en © 2020 Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Griffin, Daniel O.
Jensen, Alexandra
Khan, Mushmoom
Chin, Jessica
Chin, Kelly
Saad, Jennifer
Parnell, Ryan
Awwad, Christopher
Patel, Darshan
Cytokine storm of a different flavour: The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak
title Cytokine storm of a different flavour: The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak
title_full Cytokine storm of a different flavour: The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak
title_fullStr Cytokine storm of a different flavour: The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak
title_full_unstemmed Cytokine storm of a different flavour: The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak
title_short Cytokine storm of a different flavour: The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak
title_sort cytokine storm of a different flavour: the different cytokine signature of sars-cov-2, the cause of covid-19, from the original sars outbreak
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682938/
https://www.ncbi.nlm.nih.gov/pubmed/33242672
http://dx.doi.org/10.1016/j.jgar.2020.11.005
work_keys_str_mv AT griffindanielo cytokinestormofadifferentflavourthedifferentcytokinesignatureofsarscov2thecauseofcovid19fromtheoriginalsarsoutbreak
AT jensenalexandra cytokinestormofadifferentflavourthedifferentcytokinesignatureofsarscov2thecauseofcovid19fromtheoriginalsarsoutbreak
AT khanmushmoom cytokinestormofadifferentflavourthedifferentcytokinesignatureofsarscov2thecauseofcovid19fromtheoriginalsarsoutbreak
AT chinjessica cytokinestormofadifferentflavourthedifferentcytokinesignatureofsarscov2thecauseofcovid19fromtheoriginalsarsoutbreak
AT chinkelly cytokinestormofadifferentflavourthedifferentcytokinesignatureofsarscov2thecauseofcovid19fromtheoriginalsarsoutbreak
AT saadjennifer cytokinestormofadifferentflavourthedifferentcytokinesignatureofsarscov2thecauseofcovid19fromtheoriginalsarsoutbreak
AT parnellryan cytokinestormofadifferentflavourthedifferentcytokinesignatureofsarscov2thecauseofcovid19fromtheoriginalsarsoutbreak
AT awwadchristopher cytokinestormofadifferentflavourthedifferentcytokinesignatureofsarscov2thecauseofcovid19fromtheoriginalsarsoutbreak
AT pateldarshan cytokinestormofadifferentflavourthedifferentcytokinesignatureofsarscov2thecauseofcovid19fromtheoriginalsarsoutbreak

Ejemplares similares