Cardiac Adverse Events With Remdesivir in COVID-19 Infection

Since December 2019, coronavirus has gradually progressed to a pandemic with no efficacious treatment. Remdesivir is an antiviral medication and inhibitor of viral RNA dependent RNA polymerase with inhibitory action against SARS-CoV virus. Two patients diagnosed with coronavirus infection with worse...

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Detalles Bibliográficos
Autores principales: Gupta, Anupam K, Parker, Barbara M, Priyadarshi, Vikash, Parker, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682945/
https://www.ncbi.nlm.nih.gov/pubmed/33240723
http://dx.doi.org/10.7759/cureus.11132
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author Gupta, Anupam K
Parker, Barbara M
Priyadarshi, Vikash
Parker, John
author_facet Gupta, Anupam K
Parker, Barbara M
Priyadarshi, Vikash
Parker, John
author_sort Gupta, Anupam K
collection PubMed
description Since December 2019, coronavirus has gradually progressed to a pandemic with no efficacious treatment. Remdesivir is an antiviral medication and inhibitor of viral RNA dependent RNA polymerase with inhibitory action against SARS-CoV virus. Two patients diagnosed with coronavirus infection with worsening respiratory status were initiated with multimodality therapy with antibiotics, steroids and remdesivir. After initiation of remdesivir, the patients’ developed bradycardia, with one of the two also showing signs of worsening QT interval. This reverted upon stopping remdesvir therapy. The prevalence of bradycardia with prolonged QT interval is not well-known yet with this medication.
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spelling pubmed-76829452020-11-24 Cardiac Adverse Events With Remdesivir in COVID-19 Infection Gupta, Anupam K Parker, Barbara M Priyadarshi, Vikash Parker, John Cureus Cardiology Since December 2019, coronavirus has gradually progressed to a pandemic with no efficacious treatment. Remdesivir is an antiviral medication and inhibitor of viral RNA dependent RNA polymerase with inhibitory action against SARS-CoV virus. Two patients diagnosed with coronavirus infection with worsening respiratory status were initiated with multimodality therapy with antibiotics, steroids and remdesivir. After initiation of remdesivir, the patients’ developed bradycardia, with one of the two also showing signs of worsening QT interval. This reverted upon stopping remdesvir therapy. The prevalence of bradycardia with prolonged QT interval is not well-known yet with this medication. Cureus 2020-10-24 /pmc/articles/PMC7682945/ /pubmed/33240723 http://dx.doi.org/10.7759/cureus.11132 Text en Copyright © 2020, Gupta et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Gupta, Anupam K
Parker, Barbara M
Priyadarshi, Vikash
Parker, John
Cardiac Adverse Events With Remdesivir in COVID-19 Infection
title Cardiac Adverse Events With Remdesivir in COVID-19 Infection
title_full Cardiac Adverse Events With Remdesivir in COVID-19 Infection
title_fullStr Cardiac Adverse Events With Remdesivir in COVID-19 Infection
title_full_unstemmed Cardiac Adverse Events With Remdesivir in COVID-19 Infection
title_short Cardiac Adverse Events With Remdesivir in COVID-19 Infection
title_sort cardiac adverse events with remdesivir in covid-19 infection
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682945/
https://www.ncbi.nlm.nih.gov/pubmed/33240723
http://dx.doi.org/10.7759/cureus.11132
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