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Coronavirus disease 2019 (COVID-19) and pediatric gastroenterology

The coronavirus disease 2019 (COVID-19) is responsible for the new pandemic, which remains an important health and economic challenge worldwide. The causative agent is a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is similar to SARS-CoV-1 and Middle E...

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Autores principales: Rohani, Pejman, Ahmadi Badi, , Sara, Moshiri, Arfa, Siadat, Seyed Davar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682976/
https://www.ncbi.nlm.nih.gov/pubmed/33244377
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author Rohani, Pejman
Ahmadi Badi, , Sara
Moshiri, Arfa
Siadat, Seyed Davar
author_facet Rohani, Pejman
Ahmadi Badi, , Sara
Moshiri, Arfa
Siadat, Seyed Davar
author_sort Rohani, Pejman
collection PubMed
description The coronavirus disease 2019 (COVID-19) is responsible for the new pandemic, which remains an important health and economic challenge worldwide. The causative agent is a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is similar to SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Adult infection with respiratory symptoms was considered in the beginning of the pandemic. Now, it has been reported that SARS-CoV-2 infects children and other organs such as the gastrointestinal tract. SARS-CoV-2 enters the host cells through angiotensin converting enzyme-2 (ACE2) receptors as the main receptor expressed in various organs such as the lungs and gastrointestinal tract. Studies on children and the clinical manifestations of COVID-19 do not completely explain the natural course of infection in children, and precisely how the GI tract is involved is not understood. The present article highlights the gastrointestinal manifestations and pathological findings in children with COVID-19. According to the evidence, SARS-CoV-2 infection is milder in children and may present different clinical symptoms from adults. Common clinical manifestations of pediatric COVID-19 include cough, fever, sore throat, malaise, fatigue, and GI symptoms such as diarrhea, abdominal pain, nausea, and vomiting. Furthermore, liver and pancreatic enzymes may be elevated during the pediatric COVID-19 course. Asymptomatic children carriers are potential sources of infection for adults, especially elderly ones. Diagnosis, treatment, and isolation of children are the most effective ways to control the expansion of the COVID-19 pandemic.
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spelling pubmed-76829762020-11-25 Coronavirus disease 2019 (COVID-19) and pediatric gastroenterology Rohani, Pejman Ahmadi Badi, , Sara Moshiri, Arfa Siadat, Seyed Davar Gastroenterol Hepatol Bed Bench Mini Review The coronavirus disease 2019 (COVID-19) is responsible for the new pandemic, which remains an important health and economic challenge worldwide. The causative agent is a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is similar to SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Adult infection with respiratory symptoms was considered in the beginning of the pandemic. Now, it has been reported that SARS-CoV-2 infects children and other organs such as the gastrointestinal tract. SARS-CoV-2 enters the host cells through angiotensin converting enzyme-2 (ACE2) receptors as the main receptor expressed in various organs such as the lungs and gastrointestinal tract. Studies on children and the clinical manifestations of COVID-19 do not completely explain the natural course of infection in children, and precisely how the GI tract is involved is not understood. The present article highlights the gastrointestinal manifestations and pathological findings in children with COVID-19. According to the evidence, SARS-CoV-2 infection is milder in children and may present different clinical symptoms from adults. Common clinical manifestations of pediatric COVID-19 include cough, fever, sore throat, malaise, fatigue, and GI symptoms such as diarrhea, abdominal pain, nausea, and vomiting. Furthermore, liver and pancreatic enzymes may be elevated during the pediatric COVID-19 course. Asymptomatic children carriers are potential sources of infection for adults, especially elderly ones. Diagnosis, treatment, and isolation of children are the most effective ways to control the expansion of the COVID-19 pandemic. Shaheed Beheshti University of Medical Sciences 2020 /pmc/articles/PMC7682976/ /pubmed/33244377 Text en ©2020 RIGLD, Research Institute for Gastroenterology and Liver Diseases This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini Review
Rohani, Pejman
Ahmadi Badi, , Sara
Moshiri, Arfa
Siadat, Seyed Davar
Coronavirus disease 2019 (COVID-19) and pediatric gastroenterology
title Coronavirus disease 2019 (COVID-19) and pediatric gastroenterology
title_full Coronavirus disease 2019 (COVID-19) and pediatric gastroenterology
title_fullStr Coronavirus disease 2019 (COVID-19) and pediatric gastroenterology
title_full_unstemmed Coronavirus disease 2019 (COVID-19) and pediatric gastroenterology
title_short Coronavirus disease 2019 (COVID-19) and pediatric gastroenterology
title_sort coronavirus disease 2019 (covid-19) and pediatric gastroenterology
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682976/
https://www.ncbi.nlm.nih.gov/pubmed/33244377
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