Does Serum Urate Change as Parkinson’s Disease Progresses?

Higher serum urate concentration is associated with decreased risk of Parkinson’s disease (PD) as well as slower disease progression, but its relationship with severity of PD remains unclear. This study investigated whether changes in serum urate concentration over 5 years were associated with disea...

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Detalles Bibliográficos
Autores principales: Hasimoglu, Yasemin G., Chen, Xiqun, Bakshi, Rachit, Schwarzschild, Michael A., Macklin, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683051/
https://www.ncbi.nlm.nih.gov/pubmed/32773396
http://dx.doi.org/10.3233/JPD-202064
Descripción
Sumario:Higher serum urate concentration is associated with decreased risk of Parkinson’s disease (PD) as well as slower disease progression, but its relationship with severity of PD remains unclear. This study investigated whether changes in serum urate concentration over 5 years were associated with disease progression assessed by MDS-UPDRS Part III score, Hoehn and Yahr stage, or DaTscan imaging. Average serum urate concentration was stable over time and change in serum urate concentration did not correlate with worsening of measures of PD progression. These results suggest that serum urate concentration is not a monitoring biomarker of PD progression in early stages.

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