Does Serum Urate Change as Parkinson’s Disease Progresses?

Higher serum urate concentration is associated with decreased risk of Parkinson’s disease (PD) as well as slower disease progression, but its relationship with severity of PD remains unclear. This study investigated whether changes in serum urate concentration over 5 years were associated with disea...

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Autores principales: Hasimoglu, Yasemin G., Chen, Xiqun, Bakshi, Rachit, Schwarzschild, Michael A., Macklin, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683051/
https://www.ncbi.nlm.nih.gov/pubmed/32773396
http://dx.doi.org/10.3233/JPD-202064
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author Hasimoglu, Yasemin G.
Chen, Xiqun
Bakshi, Rachit
Schwarzschild, Michael A.
Macklin, Eric A.
author_facet Hasimoglu, Yasemin G.
Chen, Xiqun
Bakshi, Rachit
Schwarzschild, Michael A.
Macklin, Eric A.
author_sort Hasimoglu, Yasemin G.
collection PubMed
description Higher serum urate concentration is associated with decreased risk of Parkinson’s disease (PD) as well as slower disease progression, but its relationship with severity of PD remains unclear. This study investigated whether changes in serum urate concentration over 5 years were associated with disease progression assessed by MDS-UPDRS Part III score, Hoehn and Yahr stage, or DaTscan imaging. Average serum urate concentration was stable over time and change in serum urate concentration did not correlate with worsening of measures of PD progression. These results suggest that serum urate concentration is not a monitoring biomarker of PD progression in early stages.
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spelling pubmed-76830512020-12-03 Does Serum Urate Change as Parkinson’s Disease Progresses? Hasimoglu, Yasemin G. Chen, Xiqun Bakshi, Rachit Schwarzschild, Michael A. Macklin, Eric A. J Parkinsons Dis Short Communication Higher serum urate concentration is associated with decreased risk of Parkinson’s disease (PD) as well as slower disease progression, but its relationship with severity of PD remains unclear. This study investigated whether changes in serum urate concentration over 5 years were associated with disease progression assessed by MDS-UPDRS Part III score, Hoehn and Yahr stage, or DaTscan imaging. Average serum urate concentration was stable over time and change in serum urate concentration did not correlate with worsening of measures of PD progression. These results suggest that serum urate concentration is not a monitoring biomarker of PD progression in early stages. IOS Press 2020-10-27 /pmc/articles/PMC7683051/ /pubmed/32773396 http://dx.doi.org/10.3233/JPD-202064 Text en © 2020 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Hasimoglu, Yasemin G.
Chen, Xiqun
Bakshi, Rachit
Schwarzschild, Michael A.
Macklin, Eric A.
Does Serum Urate Change as Parkinson’s Disease Progresses?
title Does Serum Urate Change as Parkinson’s Disease Progresses?
title_full Does Serum Urate Change as Parkinson’s Disease Progresses?
title_fullStr Does Serum Urate Change as Parkinson’s Disease Progresses?
title_full_unstemmed Does Serum Urate Change as Parkinson’s Disease Progresses?
title_short Does Serum Urate Change as Parkinson’s Disease Progresses?
title_sort does serum urate change as parkinson’s disease progresses?
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683051/
https://www.ncbi.nlm.nih.gov/pubmed/32773396
http://dx.doi.org/10.3233/JPD-202064
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