Cargando…

Data-Driven Modeling of Knowledge Assemblies in Understanding Comorbidity Between Type 2 Diabetes Mellitus and Alzheimer’s Disease

BACKGROUND: Recent studies have suggested comorbid association between Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) through identification of shared molecular mechanisms. However, the inference is pre-dominantly literature-based and lacks interpretation of pre-disposed genomic varian...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karki, Reagon, Madan, Sumit, Gadiya, Yojana, Domingo-Fernández, Daniel, Kodamullil, Alpha Tom, Hofmann-Apitius, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683056/ https://www.ncbi.nlm.nih.gov/pubmed/32925069 http://dx.doi.org/10.3233/JAD-200752

Ejemplares similares

Comorbidity Analysis between Alzheimer’s Disease and Type 2 Diabetes Mellitus (T2DM) Based on Shared Pathways and the Role of T2DM Drugs
por: Karki, Reagon, et al.
Publicado: (2017)

COVID-19 Knowledge Graph: a computable, multi-modal, cause-and-effect knowledge model of COVID-19 pathophysiology
por: Domingo-Fernández, Daniel, et al.
Publicado: (2020)

Of Mice and Men: Comparative Analysis of Neuro-Inflammatory Mechanisms in Human and Mouse Using Cause-and-Effect Models
por: Kodamullil, Alpha Tom, et al.
Publicado: (2017)

DecoPath: a web application for decoding pathway enrichment analysis
por: Mubeen, Sarah, et al.
Publicado: (2021)

Quantifying mechanisms in neurodegenerative diseases (NDDs) using candidate mechanism perturbation amplitude (CMPA) algorithm
por: Karki, Reagon, et al.
Publicado: (2019)

Linking COVID-19 and Heme-Driven Pathophysiologies: A Combined Computational–Experimental Approach
por: Hopp, Marie-Thérèse, et al.
Publicado: (2021)

A Systems Biology Approach for Hypothesizing the Effect of Genetic Variants on Neuroimaging Features in Alzheimer’s Disease
por: Golriz Khatami, Sepehr, et al.
Publicado: (2021)

Mpox Knowledge Graph: a comprehensive representation embedding chemical entities and associated biology of Mpox
por: Karki, Reagon, et al.
Publicado: (2023)

Using Drugs as Molecular Probes: A Computational Chemical Biology Approach in Neurodegenerative Diseases
por: Emon, Mohammad Asif Emran Khan, et al.
Publicado: (2017)

Pharmacophore-Based Machine Learning Model To Predict Ligand Selectivity for E3 Ligase Binders
por: Karki, Reagon, et al.
Publicado: (2023)

Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment
por: Domingo-Fernández, Daniel, et al.
Publicado: (2017)

On the influence of several factors on pathway enrichment analysis
por: Mubeen, Sarah, et al.
Publicado: (2022)

PEMT: a patent enrichment tool for drug discovery
por: Gadiya, Yojana, et al.
Publicado: (2022)

Reasoning over genetic variance information in cause-and-effect models of neurodegenerative diseases
por: Naz, Mufassra, et al.
Publicado: (2016)

Towards a global investigation of transcriptomic signatures through co-expression networks and pathway knowledge for the identification of disease mechanisms
por: Figueiredo, Rebeca Queiroz, et al.
Publicado: (2021)

Computational Modelling Approaches on Epigenetic Factors in Neurodegenerative and Autoimmune Diseases and Their Mechanistic Analysis
por: Khanam Irin, Afroza, et al.
Publicado: (2015)

A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization
por: Schultz, Bruce, et al.
Publicado: (2021)

Training and evaluation corpora for the extraction of causal relationships encoded in biological expression language (BEL)
por: Fluck, Juliane, et al.
Publicado: (2016)

Using predictive machine learning models for drug response simulation by calibrating patient-specific pathway signatures
por: Golriz Khatami, Sepehr, et al.
Publicado: (2021)

Design of the formalized and integrated Alzheimer’s Disease Ontology and its application in retrieving textual data via text mining
por: Zhang, Bide, et al.
Publicado: (2023)

STonKGs: a sophisticated transformer trained on biomedical text and knowledge graphs
por: Balabin, Helena, et al.
Publicado: (2022)

CTO: a Community-Based Clinical Trial Ontology and its Applications in PubChemRDF and SCAIView
por: LIN, Asiyah Yu, et al.
Publicado: (2020)

Ensembles of knowledge graph embedding models improve predictions for drug discovery
por: Rivas-Barragan, Daniel, et al.
Publicado: (2022)

Elucidating gene expression patterns across multiple biological contexts through a large-scale investigation of transcriptomic datasets
por: Figueiredo, Rebeca Queiroz, et al.
Publicado: (2022)

The Epilepsy Ontology: a community-based ontology tailored for semantic interoperability and text mining
por: Sargsyan, Astghik, et al.
Publicado: (2023)

Contribution of syndecans to cellular uptake and fibrillation of α-synuclein and tau
por: Hudák, Anett, et al.
Publicado: (2019)

Exploring the Complex Network of Heme-Triggered Effects on the Blood Coagulation System
por: Mubeen, Sarah, et al.
Publicado: (2022)

PDON: Parkinson’s disease ontology for representation and modeling of the Parkinson’s disease knowledge domain
por: Younesi, Erfan, et al.
Publicado: (2015)

The COVID-19 Ontology
por: Sargsyan, Astghik, et al.
Publicado: (2020)

PTSD Biomarker Database: deep dive metadatabase for PTSD biomarkers, visualizations and analysis tools
por: Domingo-Fernández, Daniel, et al.
Publicado: (2019)

Exploring the known chemical space of the plant kingdom: insights into taxonomic patterns, knowledge gaps, and bioactive regions
por: Domingo-Fernández, Daniel, et al.
Publicado: (2023)

Realistic simulation of virtual multi-scale, multi-modal patient trajectories using Bayesian networks and sparse auto-encoders
por: Sood, Meemansa, et al.
Publicado: (2020)

Integrative data semantics through a model-enabled data stewardship
por: Wegner, Philipp, et al.
Publicado: (2022)

Multi-ontology embeddings approach on human-aligned multi-ontologies representation for gene-disease associations prediction()
por: Wang, Yihao, et al.
Publicado: (2023)

A systematic approach for identifying shared mechanisms in epilepsy and its comorbidities
por: Hoyt, Charles Tapley, et al.
Publicado: (2018)

Bioinformatics Mining and Modeling Methods for the Identification of Disease Mechanisms in Neurodegenerative Disorders
por: Hofmann-Apitius, Martin, et al.
Publicado: (2015)

Deep learning for clustering of multivariate clinical patient trajectories with missing values
por: de Jong, Johann, et al.
Publicado: (2019)

CLEP: a hybrid data- and knowledge-driven framework for generating patient representations
por: Bharadhwaj, Vinay Srinivas, et al.
Publicado: (2021)

Evaluating the Alzheimer's disease data landscape
por: Birkenbihl, Colin, et al.
Publicado: (2020)

ADataViewer: exploring semantically harmonized Alzheimer’s disease cohort datasets
por: Salimi, Yasamin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lv1lr6su89qha3ogopgniab2qg