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Trends of neglected Plasmodium species infection in humans over the past century in India

BACKGROUND: Efforts for malaria elimination in India focus solely on the more prevalent human malaria parasites of Plasmodium falciparum (Pf) and Plasmodium vivax (Pv). The three non-Pf/Pv species - Plasmodium malariae (Pm), Plasmodium ovale (Po) and Plasmodium knowlesi (Pk) are seldom studied thoug...

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Autores principales: Chaturvedi, Rini, Deora, Nimita, Bhandari, Deepam, Parvez, Suhel, Sinha, Abhinav, Sharma, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683271/
https://www.ncbi.nlm.nih.gov/pubmed/33251321
http://dx.doi.org/10.1016/j.onehlt.2020.100190
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author Chaturvedi, Rini
Deora, Nimita
Bhandari, Deepam
Parvez, Suhel
Sinha, Abhinav
Sharma, Amit
author_facet Chaturvedi, Rini
Deora, Nimita
Bhandari, Deepam
Parvez, Suhel
Sinha, Abhinav
Sharma, Amit
author_sort Chaturvedi, Rini
collection PubMed
description BACKGROUND: Efforts for malaria elimination in India focus solely on the more prevalent human malaria parasites of Plasmodium falciparum (Pf) and Plasmodium vivax (Pv). The three non-Pf/Pv species - Plasmodium malariae (Pm), Plasmodium ovale (Po) and Plasmodium knowlesi (Pk) are seldom studied though they are often present as mixed infections with Pf/Pv and thus may be misdiagnosed. This study provides a comprehensive landscape of Pm, Po, and Pk infections from 1930 to 2020. METHODOLOGY: We systematically searched for published literature on Pm, Po, and Pk in India from PubMed database and collated data from 35 studies. The data, starting from 1930, were mapped decade-wise across India. The prevalence of the three neglected Plasmodium species and their proportional contribution to reported Plasmodium mixed-infection were also calculated and analysed. PRINCIPAL FINDINGS: Amongst the three non-Pf/Pv species, Pm infections have been reported in greater numbers across India and were mostly mono-infections till 1980. From 1983 onwards, reports of Pm mixed infections with Pf/Pv started to emerge. In contrast, reports on occurrence of Po are still rare barring few mixed infection studies. Further, Pk mono- and mixed cases were first reported in 2004 in India and Pk now has been found reported from four Indian states. CONCLUSION: This is the first account of country-wide assimilation of reported malaria parasite species data that covers Pm, Po, and Pk infection profiles from 1930 to 2020. This study illustrates the need to survey all 5 human malaria parasite species in India and to target them collectively during the malaria elimination phase.
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spelling pubmed-76832712020-11-27 Trends of neglected Plasmodium species infection in humans over the past century in India Chaturvedi, Rini Deora, Nimita Bhandari, Deepam Parvez, Suhel Sinha, Abhinav Sharma, Amit One Health Research Paper BACKGROUND: Efforts for malaria elimination in India focus solely on the more prevalent human malaria parasites of Plasmodium falciparum (Pf) and Plasmodium vivax (Pv). The three non-Pf/Pv species - Plasmodium malariae (Pm), Plasmodium ovale (Po) and Plasmodium knowlesi (Pk) are seldom studied though they are often present as mixed infections with Pf/Pv and thus may be misdiagnosed. This study provides a comprehensive landscape of Pm, Po, and Pk infections from 1930 to 2020. METHODOLOGY: We systematically searched for published literature on Pm, Po, and Pk in India from PubMed database and collated data from 35 studies. The data, starting from 1930, were mapped decade-wise across India. The prevalence of the three neglected Plasmodium species and their proportional contribution to reported Plasmodium mixed-infection were also calculated and analysed. PRINCIPAL FINDINGS: Amongst the three non-Pf/Pv species, Pm infections have been reported in greater numbers across India and were mostly mono-infections till 1980. From 1983 onwards, reports of Pm mixed infections with Pf/Pv started to emerge. In contrast, reports on occurrence of Po are still rare barring few mixed infection studies. Further, Pk mono- and mixed cases were first reported in 2004 in India and Pk now has been found reported from four Indian states. CONCLUSION: This is the first account of country-wide assimilation of reported malaria parasite species data that covers Pm, Po, and Pk infection profiles from 1930 to 2020. This study illustrates the need to survey all 5 human malaria parasite species in India and to target them collectively during the malaria elimination phase. Elsevier 2020-10-28 /pmc/articles/PMC7683271/ /pubmed/33251321 http://dx.doi.org/10.1016/j.onehlt.2020.100190 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Chaturvedi, Rini
Deora, Nimita
Bhandari, Deepam
Parvez, Suhel
Sinha, Abhinav
Sharma, Amit
Trends of neglected Plasmodium species infection in humans over the past century in India
title Trends of neglected Plasmodium species infection in humans over the past century in India
title_full Trends of neglected Plasmodium species infection in humans over the past century in India
title_fullStr Trends of neglected Plasmodium species infection in humans over the past century in India
title_full_unstemmed Trends of neglected Plasmodium species infection in humans over the past century in India
title_short Trends of neglected Plasmodium species infection in humans over the past century in India
title_sort trends of neglected plasmodium species infection in humans over the past century in india
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683271/
https://www.ncbi.nlm.nih.gov/pubmed/33251321
http://dx.doi.org/10.1016/j.onehlt.2020.100190
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