Cargando…

Reversible Contraceptive Potential of FDA Approved Excipient N, N-Dimethylacetamide in Male Rats

Development of an effective male contraceptive agent remains a challenge. The present study evaluates the potential of N, N-Dimethylacetamide (DMA), a FDA approved excipient as a male contraceptive agent. Male Sprague Dawley rats injected with DMA for a period of 8 weeks (one injection per week) sho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khera, Nupur, Ghayor, Chafik, Lindholm, Anna K., Pavlova, Ekaterina, Atanassova, Nina, Weber, Franz E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683412/ https://www.ncbi.nlm.nih.gov/pubmed/33240111 http://dx.doi.org/10.3389/fphys.2020.601084

Ejemplares similares

N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment
por: Ghayor, Chafik, et al.
Publicado: (2017)

The Release of the Bromodomain Ligand N,N-Dimethylacetamide Adds Bioactivity to a Resorbable Guided Bone Regeneration Membrane in a Rabbit Calvarial Defect Model
por: Siegenthaler, Barbara, et al.
Publicado: (2020)

Effect of N-Vinyl-2-Pyrrolidone (NVP), a Bromodomain-Binding Small Chemical, on Osteoblast and Osteoclast Differentiation and Its Potential Application for Bone Regeneration
por: Klemmer, Viviane A., et al.
Publicado: (2021)

2-Cyano-N,N-dimethylacetamide
por: Liu, Shan, et al.
Publicado: (2012)

Urea–N,N-dimethylacetamide (1/1)
por: Fernandes, Philippe, et al.
Publicado: (2008)

N,N-Dimethlyacetamide Prevents the High-Fat Diet-Induced Increase in Body Weight
por: Bhattacharya, Indranil, et al.
Publicado: (2019)

Recent Uses of N,N-Dimethylformamide and N,N-Dimethylacetamide as Reagents
por: Le Bras, Jean, et al.
Publicado: (2018)

The bromodomain inhibitor N-methyl pyrrolidone reduced fat accumulation in an ovariectomized rat model
por: Gjoksi, Bebeka, et al.
Publicado: (2016)

The Bromodomain Inhibitor N-Methyl pyrrolidone Prevents Osteoporosis and BMP-Triggered Sclerostin Expression in Osteocytes
por: Siegenthaler, Barbara, et al.
Publicado: (2018)

Benzene-1,4-dicarboxylic acid–N,N-dimethylacetamide (1/2)
por: Guo, Xia, et al.
Publicado: (2009)

N,N-dimethylacetamide targets neuroinflammation in Alzheimer’s disease in in-vitro and ex-vivo models
por: Wei, Zeng-Hui, et al.
Publicado: (2023)

A Journey from June 2018 to October 2021 with N,N-Dimethylformamide and N,N-Dimethylacetamide as Reactants
por: Muzart, Jacques
Publicado: (2021)

Epigenetic Regulation of Bone Remodeling and Its Impacts in Osteoporosis
por: Ghayor, Chafik, et al.
Publicado: (2016)

Osteoconductive Microarchitecture of Bone Substitutes for Bone Regeneration Revisited
por: Ghayor, Chafik, et al.
Publicado: (2018)

N,N′-Bis(4-methylphenyl)naphthalene-1,4-dicarboxamide N,N-dimethylacetamide disolvate
por: Jing, Lin-Hai
Publicado: (2008)

N,N′-Bis(4-bromophenyl)naphthalene-1,4-dicarboxamide N,N-dimethylacetamide disolvate
por: Jing, Lin-Hai
Publicado: (2009)

N,N-Dimethylacetamide–4-iodobenzenesulfonic acid–water (1/1/1)
por: Liu, Rui, et al.
Publicado: (2008)

Study on the Mixed Electrolyte of N,N-Dimethylacetamide/Sulfolane and Its Application in Aprotic Lithium–Air Batteries
por: Wang, Fang, et al.
Publicado: (2017)

Influence of Scaffold Microarchitecture on Angiogenesis and Regulation of Cell Differentiation during the Early Phase of Bone Healing: A Transcriptomics and Histological Analysis
por: Guerrero, Julien, et al.
Publicado: (2023)

Triply Periodic Minimal Surface-Based Scaffolds for Bone Tissue Engineering: A Mechanical, In Vitro and In Vivo Study
por: Maevskaia, Ekaterina, et al.
Publicado: (2023)

Concentration determination of urinary metabolites of N,N-dimethylacetamide by high-performance liquid chromatography-tandem mass spectrometry
por: Yamamoto, Shinobu, et al.
Publicado: (2017)

ISS-N1 makes the First FDA-approved Drug for Spinal Muscular Atrophy
por: Ottesen, Eric W.
Publicado: (2017)

FDA Approvals of Biologics in 2022
por: Martins, Alexander C., et al.
Publicado: (2023)

Drugs, Devices, and the FDA: Part 2: An Overview of Approval Processes: FDA Approval of Medical Devices
por: Van Norman, Gail A.
Publicado: (2016)

Poly[(μ(4)-benzene-1,3,5-tricarboxylato)bis(N,N-dimethylacetamide)terbium(III)]
por: Liu, Kun
Publicado: (2012)

catena-Poly[[[bis(methylamine)zinc(II)]-μ-4,4′-oxydibenzoato] N,N-dimethylacetamide solvate]
por: Xu, Xianzhu, et al.
Publicado: (2007)

Nanostructure domains, voids, and low-frequency spectra in binary mixtures of N,N-dimethylacetamide and ionic liquids with varying cationic size
por: Reddy, Th. Dhileep N., et al.
Publicado: (2020)

Osteoconductivity of bone substitutes with filament-based microarchitectures: Influence of directionality, filament dimension, and distance
por: Guerrero, Julien, et al.
Publicado: (2022)

Three-Dimensional Printed Hydroxyapatite Bone Substitutes Designed by a Novel Periodic Minimal Surface Algorithm Are Highly Osteoconductive
por: Maevskaia, Ekaterina, et al.
Publicado: (2023)

Why Did the FDA Approve These Advertisements?
por: Oaks, David
Publicado: (2006)

FDA approved ready to use phenylephrine
por: Bhatia, Pradeep Kumar, et al.
Publicado: (2021)

An insider's perspective on FDA approval of aducanumab
por: Wang, Yaning
Publicado: (2023)

Alchemical analysis of FDA approved drugs
por: Orsi, Markus, et al.
Publicado: (2023)

New insights into the treatment of real N,N-dimethylacetamide contaminated wastewater using a membrane bioreactor and its membrane fouling implications
por: Zhuo, Maoshui, et al.
Publicado: (2018)

Fibrin Hydrogel Based Bone Substitute Tethered with BMP-2 and BMP-2/7 Heterodimers
por: Karfeld-Sulzer, Lindsay S., et al.
Publicado: (2015)

From Influenza Virus to Novel Corona Virus (SARS-CoV-2)–The Contribution of Obesity
por: Bhattacharya, Indranil, et al.
Publicado: (2020)

Crystal structures and Hirshfeld surface analyses of N,N-dimethylacetamide–1-(dimethyl-λ(4)-azanylidene)ethan-1-ol tribromide (1/1), N,N-dimethylacetamide–1-(dimethyl-λ(4)-azanylidene)ethan-1-ol dibromidoiodate (1/1) and N,N-dimethylacetamide–1-(dimethyl-λ(4)-azanylidene)ethan-1-ol dichloridoiodate (1/1)
por: Mammadova, Gunay Z., et al.
Publicado: (2023)

Flow cytometry data on the effect of dimethylacetamide and N-methylacetamide used at different concentrations on the quality of cryopreserved chicken semen
por: Madeddu, Manuela, et al.
Publicado: (2023)

Pulp-Derived Exosomes in a Fibrin-Based Regenerative Root Filling Material
por: Ivica, Anja, et al.
Publicado: (2020)

3D-Printed HA-Based Scaffolds for Bone Regeneration: Microporosity, Osteoconduction and Osteoclastic Resorption
por: Ghayor, Chafik, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dbq8gcav78fa9aoah635gi2f4i